Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CASP6 | P55212 | 1/20 | 0.48 |
| ▸ | PLAU | P00749 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | CASP1 | P29466 | 3/20 | 0.40 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4757272 | 0.77 | KDM4E (0.40) | KDM4EMAPTTSHRKMT2ACYP2A6 | |
| SCHEMBL4755792 | 0.74 | ALDH1A1 (0.50) | KDM4ELMNAPOLBCASP6SMN1; SMN2 | |
| SCHEMBL521935 | 0.74 | NQO2 (0.46) | KDM4EPOLBSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL1230212 | 0.69 | KMT2A (0.64) | KDM4ELMNAPOLBCASP6PLAU | |
| SCHEMBL29711628 | 0.69 | KMT2A (0.64) | KDM4ELMNAPOLBCASP6PLAU | |
| SCHEMBL30343134 | 0.69 | KMT2A (0.53) | KDM4ELMNAPOLBCASP6PLAU | |
| SCHEMBL1770021 | 0.69 | KMT2A (0.53) | KDM4ELMNAPOLBCASP6PLAU | |
| SCHEMBL12500744 | 0.68 | KDM4E (0.57) | KDM4ELMNAPOLBCASP6PLAU | |
| SCHEMBL29847851 | 0.68 | KDM4E (0.57) | KDM4ELMNAPOLBCASP6PLAU | |
| SCHEMBL7630593 | 0.68 | KDM4E (0.52) | KDM4ELMNAPOLBCASP6PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008154905-A2 | MODIFICATIONS OF THE HISTONE DEACETYLASE INHIBITOR SUBEROYLANILIDE HYDROXAMIC ACID | SCHEBO BIOTECH AG (DE) | 2008-12-24 | — | — | WO | disclosed |