Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ACLY | P53396 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2930564 | 0.81 | ACLY (0.51) | CXCR2L3MBTL1ALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL2930565 | 0.81 | ACLY (0.51) | CXCR2L3MBTL1ALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL4757644 | 0.81 | ACLY (0.51) | CXCR2L3MBTL1ALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL4757347 | 0.76 | TDP1 (0.42) | CXCR2L3MBTL1ALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL2929510 | 0.71 | GAA (0.45) | ALDH1A1SMN1; SMN2TDP1TSHRUSP2 | |
| SCHEMBL2927961 | 0.71 | GAA (0.45) | ALDH1A1SMN1; SMN2TDP1TSHRUSP2 | |
| SCHEMBL2927960 | 0.71 | GAA (0.45) | ALDH1A1SMN1; SMN2TDP1TSHRUSP2 | |
| SCHEMBL3896759 | 0.67 | TDP1 (0.67) | L3MBTL1ALDH1A1SMN1; SMN2TDP1RXFP1 | |
| SCHEMBL1020561 | 0.67 | KMT2A (0.63) | L3MBTL1ALDH1A1TP53SMN1; SMN2RXFP1 | |
| SCHEMBL4759367 | 0.65 | ACLY (0.53) | L3MBTL1ALDH1A1SMN1; SMN2NPC1ACLY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534695-A4 | TYROSINE KINASE INHIBITORS | MERCK & CO INC (US) | 2008-06-11 | — | — | EP | disclosed |
| EP-1534695-A2 | TYROSINE KINASE INHIBITORS | Merck & Co., Inc. (US) | 2005-06-01 | — | — | EP | disclosed |
| WO-2004014851-A2 | TYROSINE KINASE INHIBITORS | MERCK & CO., INC. (US) | 2004-02-19 | — | — | WO | disclosed |