Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 3/20 | 0.42 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.36 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4753971 | 0.86 | LTA4H (0.53) | LTA4HKMT2AALDH1A1SIGMAR1 | |
| SCHEMBL31688124 | 0.83 | LTA4H (0.44) | LTA4HPRKG1MEN1KMT2AALDH1A1 | |
| SCHEMBL3036067 | 0.83 | LTA4H (0.44) | LTA4HPRKG1MEN1KMT2AALDH1A1 | |
| SCHEMBL4753500 | 0.81 | LTA4H (0.44) | LTA4HMEN1KMT2AALDH1A1SIGMAR1 | |
| SCHEMBL3039178 | 0.81 | LTA4H (0.45) | LTA4HPRKG1MEN1KMT2AALDH1A1 | |
| SCHEMBL31688123 | 0.81 | LTA4H (0.45) | LTA4HPRKG1MEN1KMT2AALDH1A1 | |
| SCHEMBL4757592 | 0.81 | LTA4H (0.38) | LTA4HMEN1KMT2ASIGMAR1 | |
| SCHEMBL3030395 | 0.80 | LTA4H (0.44) | LTA4HPRKG1MEN1KMT2AALDH1A1 | |
| SCHEMBL3038994 | 0.76 | LTA4H (0.57) | LTA4HMEN1KMT2AALDH1A1TSHR | |
| SCHEMBL3038998 | 0.76 | KMT2A (0.39) | LTA4HMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1976828-A1 | DIAMINE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE A4 HYDROLASE | Schering Aktiengesellschaft (DE) | 2008-10-08 | — | — | EP | disclosed |
| WO-2007079078-A1 | DIAMINE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE A4 HYDROLASE | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2007-07-12 | — | — | WO | disclosed |