Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4753971 | 0.88 | LTA4H (0.53) | LTA4HKMT2AALDH1A1SIGMAR1 | |
| SCHEMBL4757643 | 0.81 | LTA4H (0.42) | LTA4HMEN1KMT2AALDH1A1SIGMAR1 | |
| SCHEMBL3037133 | 0.80 | LTA4H (0.43) | LTA4HL3MBTL1LMNAMEN1KMT2A | |
| SCHEMBL5591610 | 0.79 | LTA4H (0.46) | LTA4HL3MBTL1LMNAMEN1KMT2A | |
| SCHEMBL3039063 | 0.79 | LTA4H (0.46) | LTA4HL3MBTL1LMNAMEN1KMT2A | |
| SCHEMBL4757592 | 0.77 | LTA4H (0.38) | LTA4HMEN1KMT2ASIGMAR1 | |
| SCHEMBL3038994 | 0.76 | LTA4H (0.57) | LTA4HMEN1KMT2AALDH1A1SIGMAR1 | |
| SCHEMBL3039580 | 0.75 | KDM4E (0.42) | LTA4HL3MBTL1LMNAMEN1KMT2A | |
| SCHEMBL14606175 | 0.72 | HDAC1 (0.50) | LTA4HL3MBTL1LMNAMEN1KMT2A | |
| SCHEMBL4757698 | 0.72 | LTA4H (0.52) | LTA4HALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1976828-A1 | DIAMINE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE A4 HYDROLASE | Schering Aktiengesellschaft (DE) | 2008-10-08 | — | — | EP | disclosed |
| WO-2007079078-A1 | DIAMINE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE A4 HYDROLASE | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2007-07-12 | — | — | WO | disclosed |