Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CMA1 | P23946 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4757643 | 0.81 | LTA4H (0.42) | LTA4HSIGMAR1MEN1KMT2A | |
| SCHEMBL4753971 | 0.80 | LTA4H (0.53) | LTA4HSIGMAR1KMT2A | |
| SCHEMBL4753500 | 0.77 | LTA4H (0.44) | LTA4HSIGMAR1MEN1KMT2A | |
| SCHEMBL3038994 | 0.69 | LTA4H (0.57) | LTA4HSIGMAR1MEN1KMT2A | |
| SCHEMBL3040613 | 0.67 | LTA4H (0.42) | LTA4HSIGMAR1S1PR1 | |
| SCHEMBL4757698 | 0.66 | LTA4H (0.52) | LTA4H | |
| SCHEMBL4755387 | 0.65 | LTA4H (0.53) | LTA4HSIGMAR1 | |
| SCHEMBL3036067 | 0.65 | LTA4H (0.44) | LTA4HSIGMAR1MEN1KMT2A | |
| SCHEMBL31688124 | 0.65 | LTA4H (0.44) | LTA4HSIGMAR1MEN1KMT2A | |
| SCHEMBL3035481 | 0.64 | LTA4H (0.43) | LTA4HSIGMAR1S1PR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1976828-A1 | DIAMINE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE A4 HYDROLASE | Schering Aktiengesellschaft (DE) | 2008-10-08 | — | — | EP | disclosed |
| WO-2007079078-A1 | DIAMINE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE A4 HYDROLASE | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2007-07-12 | — | — | WO | disclosed |