Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 9/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | GCGR | P47871 | 1/20 | 0.39 |
| ▸ | GIPR | P48546 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 6/20 | 0.38 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4755387 | 0.94 | LTA4H (0.53) | LTA4HALDH1A1TSHRHSD17B10GCGR | |
| SCHEMBL3036713 | 0.90 | LTA4H (0.56) | LTA4HALDH1A1TSHRHSD17B10GCGR | |
| SCHEMBL3038590 | 0.87 | ALDH1A1 (0.63) | LTA4HALDH1A1TSHRHSD17B10GCGR | |
| SCHEMBL3036296 | 0.84 | LTA4H (0.56) | LTA4HGCGRGIPRPTGER4TEAD1 | |
| SCHEMBL4753971 | 0.84 | LTA4H (0.53) | LTA4HALDH1A1 | |
| SCHEMBL4818032 | 0.83 | LTA4H (0.51) | LTA4HALDH1A1TSHRHSD17B10GCGR | |
| SCHEMBL3038994 | 0.81 | LTA4H (0.57) | LTA4HALDH1A1TSHR | |
| SCHEMBL3040886 | 0.79 | LTA4H (0.55) | LTA4HALDH1A1TSHRPTGER4 | |
| SCHEMBL3036716 | 0.78 | LTA4H (0.59) | LTA4HALDH1A1PTGER4 | |
| SCHEMBL4790381 | 0.78 | LTA4H (0.59) | LTA4HALDH1A1PTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1976828-A1 | DIAMINE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE A4 HYDROLASE | Schering Aktiengesellschaft (DE) | 2008-10-08 | — | — | EP | disclosed |
| WO-2007079078-A1 | DIAMINE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE A4 HYDROLASE | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2007-07-12 | — | — | WO | disclosed |