Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 5/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.31 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.31 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.31 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4758504 | 0.72 | HTR3A (0.32) | — | |
| SCHEMBL4758909 | 0.70 | KDM4E (0.37) | MAPTALDH1A1KDM4ENPC1LMNA | |
| SCHEMBL17942701 | 0.70 | ALDH1A1 (0.46) | KMT2AGAAMAPTALDH1A1KDM4E | |
| SCHEMBL1337886 | 0.68 | PNP (0.42) | GAAMAPTNUDT1CDK1 | |
| SCHEMBL4756129 | 0.68 | — | — | |
| SCHEMBL28004484 | 0.65 | PNP (0.40) | — | |
| SCHEMBL28004985 | 0.65 | PNP (0.40) | NPY5R | |
| SCHEMBL27523662 | 0.65 | PNP (0.40) | — | |
| SCHEMBL31252326 | 0.65 | CASP6 (0.47) | KMT2AGAAMAPTALDH1A1KDM4E | |
| SCHEMBL17942704 | 0.64 | BACE1 (0.46) | KMT2AGAAMAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1897882-B1 | N2-QUINOLYL OR ISOQUINOLYL SUBSTITUTED PURINE DERIVATIVES, THE PREPARATION AND USES THEREOF | ZHE JIANG MEDECINE CO LTD XINCHANG PHARMACEUTICAL FACTORY (CN) | 2014-12-10 | — | — | EP | disclosed |
| EP-1897882-A1 | N2-QUINOLYL OR ISOQUINOLYL SUBSTITUTED PURINE DERIVATIVES, THE PREPARATION AND USES THEREOF | Zhe Jiang Medecine Co., Ltd. Xinchang Pharmaceutical Factory (CN) | 2008-03-12 | — | — | EP | disclosed |