Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | GLA | P06280 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | CTSD | P07339 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | CNR2 | P34972 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.53 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4758147 | 1.00 | HPGD (0.63) | HPGDALDH1A1TP53GLANPC1 | |
| SCHEMBL14976802 | 0.88 | MEN1 (0.61) | HPGDALDH1A1TP53GLANPC1 | |
| SCHEMBL10330508 | 0.85 | HPGD (0.62) | HPGDALDH1A1TP53GLANPC1 | |
| SCHEMBL6368355 | 0.84 | ALDH1A1 (0.62) | HPGDALDH1A1TP53GLAMEN1 | |
| SCHEMBL6368357 | 0.84 | ALDH1A1 (0.62) | HPGDALDH1A1TP53GLAMEN1 | |
| SCHEMBL29619793 | 0.84 | ALDH1A1 (0.62) | HPGDALDH1A1TP53GLAMEN1 | |
| SCHEMBL14819905 | 0.83 | HPGD (0.58) | HPGDALDH1A1TP53GLANPC1 | |
| SCHEMBL28613885 | 0.83 | HPGD (0.58) | HPGDALDH1A1TP53GLARAB9A | |
| SCHEMBL24863013 | 0.82 | CAPN1 (0.66) | HPGDALDH1A1TP53GLAL3MBTL1 | |
| SCHEMBL18893131 | 0.81 | L3MBTL1 (0.74) | HPGDALDH1A1TP53GLANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001214-A2 | THIENO[2,3-D]PYRIMIDIN-4(3H)-ONE, ISOXAZOLO[5,4-D]PYRIMIDIN-4(5H)-ONE AND ISOTHIAZOLO[5,4-D]PYRIMIDIN-4(5H)-ONE DERIVATIVES AS CALCIUM RECEPTOR ANTAGONISTS | PFIZER PRODUCTS INC. (US) | 2008-12-31 | — | — | WO | disclosed |