Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | PPARA | Q07869 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27663466 | 0.85 | TSHR (0.45) | KDM4EALDH1A1MEN1KMT2AHTT | |
| SCHEMBL1165789 | 0.84 | TSHR (0.46) | KDM4EALDH1A1MEN1KMT2AHTT | |
| SCHEMBL4298978 | 0.83 | LMNA (0.46) | KDM4EALDH1A1MEN1KMT2AHTT | |
| SCHEMBL4041867 | 0.83 | TSHR (0.47) | KDM4EALDH1A1MEN1KMT2APOLB | |
| SCHEMBL6898466 | 0.78 | CYP2C19 (0.46) | KDM4EALDH1A1MEN1KMT2APOLB | |
| SCHEMBL1670311 | 0.78 | CYP2C19 (0.46) | KDM4EALDH1A1MEN1KMT2APOLB | |
| SCHEMBL3702043 | 0.78 | PPARG (0.46) | KDM4EALDH1A1MEN1KMT2AHTT | |
| Citric Acid SCHEMBL7430817 | 0.76 | KDM4E (0.45) | KDM4EALDH1A1MEN1KMT2AHTT | |
| SCHEMBL9245013 | 0.73 | CYP2C19 (0.42) | KDM4EALDH1A1MEN1KMT2AHTT | |
| SCHEMBL5322365 | 0.73 | CYP2C19 (0.42) | KDM4EALDH1A1MEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945613-A1 | NOVEL 1 -BENZYL-4-PIPERIDINAMINES THAT ARE USEFUL IN THE TREATMENT OF COPD AND ASTHMA | AstraZeneca AB (SE) | 2008-07-23 | — | — | EP | disclosed |
| WO-2007053082-A1 | NOVEL 1 -BENZYL-4-PIPERIDINAMINES THAT ARE USEFUL IN THE TREATMENT OF COPD AND ASTHMA | ASTRAZENECA AB (SE) | 2007-05-10 | — | — | WO | disclosed |