Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | GABRP | O00591 | 2/20 | 0.38 |
| ▸ | GABRD | O14764 | 2/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.38 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.38 |
| ▸ | GABRE | P78334 | 2/20 | 0.38 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.38 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.38 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22868123 | 0.84 | NNMT (0.38) | KDM4ECASP1ALDH1A1POLBTDP1 | |
| SCHEMBL20841811 | 0.83 | SMN1; SMN2 (0.44) | SMN1; SMN2LMNAKEAP1NFE2L2KDM4E | |
| SCHEMBL31481122 | 0.81 | SMN1; SMN2 (0.43) | SMN1; SMN2LMNAKEAP1NFE2L2KDM4E | |
| SCHEMBL19667222 | 0.81 | KEAP1 (0.46) | SMN1; SMN2LMNAKEAP1NFE2L2KDM4E | |
| SCHEMBL9690501 | 0.79 | GABRP (0.39) | SMN1; SMN2KDM4EGABRPGABRDGABRA1 | |
| SCHEMBL19706424 | 0.79 | GABRP (0.56) | SMN1; SMN2KDM4EGABRPGABRDGABRA1 | |
| SCHEMBL28798115 | 0.78 | RXFP1 (0.39) | SMN1; SMN2KDM4EGABRPGABRDGABRA1 | |
| SCHEMBL19913396 | 0.78 | GABRP (0.46) | KDM4EGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL11078351 | 0.77 | ALDH1A1 (0.38) | SMN1; SMN2KDM4EGABRPGABRDGABRA1 | |
| SCHEMBL5857519 | 0.77 | ALDH1A1 (0.46) | SMN1; SMN2KDM4EGABRA2GABRB2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023118092-A1 | PYRAZOLO[1,5-A]PYRIDO[3,2-E]PYRIMIDINES AND PYRAZOLO[1,5-A][1,3]THIAZOLO[5,4-E]PYRIMIDINES AS P2X3 INHIBITORS FOR THE TREATMENT OF NEUROGENIC DISORDERS | BAYER AKTIENGESELLSCHAFT (DE) | 2023-06-29 | — | — | WO | disclosed |
| US-20080194640-A1 | Optically Active Tetrahydronaphthalene Derivative | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2008-08-14 | — | — | US | disclosed |
| EP-1852431-A1 | OPTICALLY ACTIVE TETRAHYDRONAPHTHALENE DERIVATIVE | MITSUBISHI PHARMA CORPORATION (JP) | 2007-11-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194640-A1 | Optically Active Tetrahydronaphthalene Derivative | C3AR1, C5AR1, C5AR2 | SMN1; SMN2 2603/4885LMNA 2928/4885KEAP1 903/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.