Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4760636 | 0.89 | RXFP1 (0.37) | POLBMEN1KMT2AL3MBTL1SLC6A3 | |
| SCHEMBL4761085 | 0.81 | GABRA1 (0.38) | POLBMEN1KMT2AL3MBTL1SLC6A3 | |
| SCHEMBL1336997 | 0.78 | MAPK14 (0.49) | POLBMEN1KMT2AMAPK14KDM4E | |
| SCHEMBL1339208 | 0.77 | KDM4E (0.42) | MEN1KMT2ASLC6A4SLC6A3PIK3CA | |
| SCHEMBL4760558 | 0.76 | CNR1 (0.35) | POLBMEN1KMT2ASLC6A4SLC6A3 | |
| SCHEMBL1339490 | 0.70 | CHRNA7 (0.40) | MEN1KMT2AKCNH2PIK3CAKDM4E | |
| SCHEMBL1336822 | 0.69 | PTPN1 (0.43) | POLBMEN1KMT2APIK3CAKDM4E | |
| SCHEMBL1339122 | 0.68 | MAPK14 (0.35) | POLBMAPK14BRD4PIK3CAKDM4E | |
| SCHEMBL1339045 | 0.68 | MAPT (0.33) | MEN1KMT2APIK3CAKDM4EMAPT | |
| SCHEMBL1339044 | 0.68 | MAPT (0.33) | MEN1KMT2APIK3CAKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940840-A1 | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007045758-A1 | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2007-04-26 | — | — | WO | disclosed |