Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 4/20 | 0.35 |
| ▸ | CNR2 | P34972 | 4/20 | 0.35 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4760594 | 0.81 | AHR (0.38) | KCNH2MAPK14KMT2AMEN1POLB | |
| SCHEMBL1337225 | 0.80 | HPGD (0.42) | GRM2KMT2AMEN1POLBL3MBTL1 | |
| SCHEMBL1338688 | 0.79 | GABRA1 (0.41) | GABRA1GABRG2GABRB3GABRA5KCNH2 | |
| SCHEMBL4760636 | 0.76 | RXFP1 (0.37) | TRPA1KMT2AMEN1POLBL3MBTL1 | |
| SCHEMBL4760558 | 0.73 | CNR1 (0.35) | GABRA1CNR1CNR2MAPK14KMT2A | |
| SCHEMBL4761086 | 0.73 | EGFR (0.43) | GABRA1GABRG2GABRB3GABRA5CNR1 | |
| SCHEMBL3856165 | 0.70 | ALOX5AP (0.47) | PTGESPTGES2GRM2KMT2AMEN1 | |
| SCHEMBL1337266 | 0.69 | MAPT (0.43) | KMT2AMEN1POLBRXFP1RAB9A | |
| SCHEMBL1337265 | 0.69 | MAPT (0.43) | KMT2AMEN1POLBRXFP1RAB9A | |
| SCHEMBL1338090 | 0.68 | KDM4E (0.52) | KMT2AMEN1POLBRXFP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940840-A1 | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007045758-A1 | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2007-04-26 | — | — | WO | disclosed |