Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 9/20 | 0.35 |
| ▸ | CNR2 | P34972 | 9/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.33 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1338158 | 0.79 | GSK3B (0.43) | CNR1CNR2MAPTGABRA1CXCR3 | |
| SCHEMBL4760636 | 0.78 | RXFP1 (0.37) | MAPTSLC6A3RXFP1SMN1; SMN2KMT2A | |
| SCHEMBL4760594 | 0.76 | AHR (0.38) | MAPTSLC6A3MAPK14THRBSLC6A4 | |
| SCHEMBL1337392 | 0.75 | HSD17B10 (0.46) | MAPTADORA1THRBRXFP1SMN1; SMN2 | |
| SCHEMBL4761085 | 0.73 | GABRA1 (0.38) | CNR1CNR2SLC6A3EGFRALOX5 | |
| SCHEMBL1337044 | 0.71 | CXCR3 (0.39) | CNR1CNR2MAPTGABRA1SIGMAR1 | |
| SCHEMBL4760559 | 0.70 | KMT2A (0.44) | MAPTADORA1EGFRMAPK14CXCR3 | |
| SCHEMBL1339005 | 0.69 | ALDH1A1 (0.42) | CNR1CNR2MAPTSLC6A3EGFR | |
| SCHEMBL1338964 | 0.69 | GSK3B (0.41) | CXCR3PTPN1GSK3BKMT2AMEN1 | |
| SCHEMBL1336822 | 0.68 | PTPN1 (0.43) | MAPTTHRBRXFP1PTPN1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940840-A1 | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007045758-A1 | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2007-04-26 | — | — | WO | disclosed |