Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14699551 | 0.81 | L3MBTL1 (0.57) | L3MBTL1TP53MEN1KMT2AHPGD | |
| SCHEMBL6400618 | 0.78 | L3MBTL1 (0.50) | L3MBTL1TP53MEN1KMT2AHPGD | |
| SCHEMBL692444 | 0.73 | L3MBTL1 (0.58) | L3MBTL1TP53MEN1KMT2AHPGD | |
| SCHEMBL17049278 | 0.73 | RPS6KA5 (0.48) | L3MBTL1MEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL4738504 | 0.68 | SMN1; SMN2 (0.44) | L3MBTL1TP53MEN1KMT2AHPGD | |
| SCHEMBL6680308 | 0.67 | GAA (0.49) | L3MBTL1TP53MEN1KMT2AHPGD | |
| SCHEMBL14611872 | 0.67 | NPSR1 (0.51) | L3MBTL1TP53MEN1KMT2AHPGD | |
| SCHEMBL4311403 | 0.67 | GAA (0.49) | L3MBTL1TP53MEN1KMT2AHPGD | |
| SCHEMBL5738824 | 0.67 | GAA (0.56) | L3MBTL1TP53MEN1KMT2AHPGD | |
| SCHEMBL8194267 | 0.67 | GAA (0.49) | L3MBTL1TP53MEN1KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030216415-A1 | Process for preparing 2-(4-pyridyl)amino-6-dialkyloxyphenyl-pyrido[2,3-d]pyrimidin-7-ones | BEYLIN VLADIMIR GENUKH (US) | 2003-11-20 | — | — | US | claimed |
| EP-1307451-A2 | PROCESS FOR PREPARING 2-(4-PYRIDYL)AMINO-6-DIALKYLOXYPHENYL-PYRIDO 2,3-D]PYRIMIDIN-7-ONES | WARNER-LAMBERT COMPANY LLC (US) | 2003-05-07 | — | — | EP | claimed |
| WO-2002012237-A2 | PROCESS FOR PREPARING 2-(4-PYRIDYL)AMINO-6-DIALKYLOXYPHENYL-PYRIDO[2,3-D]PYRIMIDIN-7-ONES | WARNER-LAMBERT COMPANY (US) | 2002-02-14 | — | — | WO | claimed |
| EP-1307450-B1 | 2-(4-Pyridyl)amino-6-dialkoxyphenyl-pyrido(2,3-d)pyrimidin-7-ones | WARNER LAMBERT CO (US) | 2008-09-17 | — | — | EP | disclosed |
| US-7022711-B2 | 2-(4-Pyridyl)amino-6-dialkoxyphenyl-pyrido[2,3-d]pyrimidin-7-ones | WARNER-LAMBERT COMPANY (US) | 2006-04-04 | — | — | US | disclosed |
| US-6960662-B2 | Process for preparing 2-(4-pyridyl)amino-6-dialkyloxyphenyl-pyrido[2,3-d]pyrimidin-7-ones | WARNER-LAMBERT COMPANY (US) | 2005-11-01 | — | — | US | disclosed |
| EP-1417207-B1 | PROCESS FOR PREPARING 2-(4-PYRIDYL) AMINO-6-DIALKYLOXYPHENYL-PYRIDO(2,3-D)PYRIMIDIN-7-ONES | WARNER LAMBERT CO (US) | 2005-08-31 | — | — | EP | disclosed |
| US-6900316-B2 | Process for preparing 2-(4-pyridyl)amino-6-dialkyloxyphenyl-pyrido(2,3-d)pyrimidin-7-ones | WARNER-LAMBER COMPANY (US) | 2005-05-31 | — | — | US | disclosed |
| EP-1417207-A2 | PROCESS FOR PREPARING 2-(4-PYRIDYL) AMINO-6-DIALKYLOXYPHENYL-PYRIDO(2,3-D)PYRIMIDIN-7-ONES | WARNER-LAMBERT COMPANY (US) | 2004-05-12 | — | — | EP | disclosed |
| US-20030220345-A1 | 2-(4-Pyridyl)amino-6-dialkoxyphenyl-pyrido[2,3-d]pyrimdin-7-ones | HAMBY JAMES MARINO (US) | 2003-11-27 | — | — | US | disclosed |
| US-20030216415-A1 | Process for preparing 2-(4-pyridyl)amino-6-dialkyloxyphenyl-pyrido[2,3-d]pyrimidin-7-ones | BEYLIN VLADIMIR GENUKH (US) | 2003-11-20 | — | — | US | disclosed |
| US-20030176700-A1 | Process for preparing 2-(4-pyridyl)amino-6-dialkyloxyphenyl-pyrido(2,3-d)pyrimidin-7-ones | TJIONG HOWARD ISAAC (US) | 2003-09-18 | — | — | US | disclosed |
| EP-1307450-A2 | 2-(4-PYRDYL)AMINO-6-DIALKOXYPHENYL-PYRIDO(2.3-D)PYRIMIDIN-7-ONES | WARNER-LAMBERT COMPANY (US) | 2003-05-07 | — | — | EP | disclosed |
| EP-1307451-A2 | PROCESS FOR PREPARING 2-(4-PYRIDYL)AMINO-6-DIALKYLOXYPHENYL-PYRIDO 2,3-D]PYRIMIDIN-7-ONES | WARNER-LAMBERT COMPANY LLC (US) | 2003-05-07 | — | — | EP | disclosed |
| WO-2003027110-A2 | PROCESS FOR PREPARING 2-(4-PYRIDYL) AMINO-6-DIALKYLOXYPHENYL-PYRIDO [2,3-D]PYRIMIDIN-7-ONES | WARNER-LAMBERT COMPANY (US) | 2003-04-03 | — | — | WO | disclosed |
| WO-2002012238-A2 | 2-(4-PYRIDYL)AMINO-6-DIALKOXYPHENYL-PYRIDO[2,3-d]PYRIMIDIN-7-ONES | WARNER-LAMBERT COMPANY (US) | 2002-02-14 | — | — | WO | disclosed |
| WO-2002012237-A2 | PROCESS FOR PREPARING 2-(4-PYRIDYL)AMINO-6-DIALKYLOXYPHENYL-PYRIDO[2,3-D]PYRIMIDIN-7-ONES | WARNER-LAMBERT COMPANY (US) | 2002-02-14 | — | — | WO | disclosed |
| US-5945422-A | ANTICANCER AGENTS; ATHEROSCLEROSIS; RESTENOSIS; PSORIASIS | WARNER-LAMBERT COMPANY (US) | 1999-08-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030176700-A1 | Process for preparing 2-(4-pyridyl)amino-6-dialkyloxyphenyl-pyrido(2,3-d)pyrimidin-7-ones | DPYD, PDXK, AHR | L3MBTL1 4253/4885TP53 1771/4885MEN1 3124/4885 |
| US-20030216415-A1 | Process for preparing 2-(4-pyridyl)amino-6-dialkyloxyphenyl-pyrido[2,3-d]pyrimidin-7-ones | DPYD, PDXK, PARP2 | L3MBTL1 4495/4885TP53 2062/4885MEN1 3451/4885 |
| US-20030220345-A1 | 2-(4-Pyridyl)amino-6-dialkoxyphenyl-pyrido[2,3-d]pyrimdin-7-ones | FLT1, FLT4, MKI67 | L3MBTL1 4200/4885TP53 348/4885MEN1 3021/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.