Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4761063 | 0.78 | L3MBTL1 (0.50) | L3MBTL1TP53GAAHPGDRAB9A | |
| SCHEMBL14699551 | 0.78 | L3MBTL1 (0.57) | L3MBTL1TP53GAAHPGDRAB9A | |
| SCHEMBL692444 | 0.73 | L3MBTL1 (0.58) | L3MBTL1TP53GAAHPGDRAB9A | |
| SCHEMBL18193691 | 0.73 | RPS6KA5 (0.41) | TP53RAB9AKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL14805666 | 0.69 | ALDH1A1 (0.35) | TP53GAAKDM4ESMN1; SMN2ALDH1A1 | |
| SCHEMBL2563787 | 0.69 | ALDH1A1 (0.45) | L3MBTL1TP53GAAHPGDRAB9A | |
| SCHEMBL11853838 | 0.69 | L3MBTL1 (0.46) | L3MBTL1TP53GAAHPGDRAB9A | |
| SCHEMBL8571213 | 0.68 | ALDH1A1 (0.35) | KDM4EALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL6336905 | 0.68 | TSHR (0.39) | L3MBTL1GAAHPGDRAB9AKDM4E | |
| SCHEMBL4311403 | 0.67 | GAA (0.49) | L3MBTL1TP53GAAHPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1417207-B1 | PROCESS FOR PREPARING 2-(4-PYRIDYL) AMINO-6-DIALKYLOXYPHENYL-PYRIDO(2,3-D)PYRIMIDIN-7-ONES | WARNER LAMBERT CO (US) | 2005-08-31 | — | — | EP | claimed |
| US-6900316-B2 | Process for preparing 2-(4-pyridyl)amino-6-dialkyloxyphenyl-pyrido(2,3-d)pyrimidin-7-ones | WARNER-LAMBER COMPANY (US) | 2005-05-31 | — | — | US | claimed |
| EP-1417207-A2 | PROCESS FOR PREPARING 2-(4-PYRIDYL) AMINO-6-DIALKYLOXYPHENYL-PYRIDO(2,3-D)PYRIMIDIN-7-ONES | WARNER-LAMBERT COMPANY (US) | 2004-05-12 | — | — | EP | claimed |
| US-20030176700-A1 | Process for preparing 2-(4-pyridyl)amino-6-dialkyloxyphenyl-pyrido(2,3-d)pyrimidin-7-ones | TJIONG HOWARD ISAAC (US) | 2003-09-18 | — | — | US | claimed |
| WO-2003027110-A2 | PROCESS FOR PREPARING 2-(4-PYRIDYL) AMINO-6-DIALKYLOXYPHENYL-PYRIDO [2,3-D]PYRIMIDIN-7-ONES | WARNER-LAMBERT COMPANY (US) | 2003-04-03 | — | — | WO | claimed |
| US-6960662-B2 | Process for preparing 2-(4-pyridyl)amino-6-dialkyloxyphenyl-pyrido[2,3-d]pyrimidin-7-ones | WARNER-LAMBERT COMPANY (US) | 2005-11-01 | — | — | US | disclosed |
| EP-1417207-B1 | PROCESS FOR PREPARING 2-(4-PYRIDYL) AMINO-6-DIALKYLOXYPHENYL-PYRIDO(2,3-D)PYRIMIDIN-7-ONES | WARNER LAMBERT CO (US) | 2005-08-31 | — | — | EP | disclosed |
| US-6900316-B2 | Process for preparing 2-(4-pyridyl)amino-6-dialkyloxyphenyl-pyrido(2,3-d)pyrimidin-7-ones | WARNER-LAMBER COMPANY (US) | 2005-05-31 | — | — | US | disclosed |
| US-6900316-B2 | Process for preparing 2-(4-pyridyl)amino-6-dialkyloxyphenyl-pyrido(2,3-d)pyrimidin-7-ones | WARNER-LAMBER COMPANY (US) | 2005-05-31 | — | — | US | disclosed |
| EP-1417207-A2 | PROCESS FOR PREPARING 2-(4-PYRIDYL) AMINO-6-DIALKYLOXYPHENYL-PYRIDO(2,3-D)PYRIMIDIN-7-ONES | WARNER-LAMBERT COMPANY (US) | 2004-05-12 | — | — | EP | disclosed |
| US-20030216415-A1 | Process for preparing 2-(4-pyridyl)amino-6-dialkyloxyphenyl-pyrido[2,3-d]pyrimidin-7-ones | BEYLIN VLADIMIR GENUKH (US) | 2003-11-20 | — | — | US | disclosed |
| US-20030176700-A1 | Process for preparing 2-(4-pyridyl)amino-6-dialkyloxyphenyl-pyrido(2,3-d)pyrimidin-7-ones | TJIONG HOWARD ISAAC (US) | 2003-09-18 | — | — | US | disclosed |
| WO-2003027110-A2 | PROCESS FOR PREPARING 2-(4-PYRIDYL) AMINO-6-DIALKYLOXYPHENYL-PYRIDO [2,3-D]PYRIMIDIN-7-ONES | WARNER-LAMBERT COMPANY (US) | 2003-04-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030176700-A1 | Process for preparing 2-(4-pyridyl)amino-6-dialkyloxyphenyl-pyrido(2,3-d)pyrimidin-7-ones | DPYD, PDXK, AHR | L3MBTL1 4253/4885TP53 1771/4885GAA 4497/4885 |
| US-20030216415-A1 | Process for preparing 2-(4-pyridyl)amino-6-dialkyloxyphenyl-pyrido[2,3-d]pyrimidin-7-ones | DPYD, PDXK, PARP2 | L3MBTL1 4495/4885TP53 2062/4885GAA 4188/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.