Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.39 |
| ▸ | MEN1 | O00255 | 6/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4760596 | 0.78 | MAPK14 (0.52) | EGFRSRCALDH1A1KMT2AMEN1 | |
| SCHEMBL1337225 | 0.75 | HPGD (0.42) | ALDH1A1KMT2AMEN1L3MBTL1POLB | |
| SCHEMBL4760637 | 0.73 | SRC (0.48) | EGFRSRCALDH1A1KMT2AMEN1 | |
| SCHEMBL4761085 | 0.73 | GABRA1 (0.38) | EGFRKMT2AMEN1L3MBTL1POLB | |
| SCHEMBL4760559 | 0.70 | KMT2A (0.44) | EGFRSRCALDH1A1KMT2AMEN1 | |
| SCHEMBL1338688 | 0.70 | GABRA1 (0.41) | GABRA1GABRG2GABRB3GABRA5KDM4E | |
| SCHEMBL3140274 | 0.69 | KDM4E (0.44) | ALDH1A1KMT2AMEN1POLBKDM4E | |
| SCHEMBL1338090 | 0.66 | KDM4E (0.52) | ALDH1A1KMT2AMEN1POLBKDM4E | |
| SCHEMBL11736340 | 0.65 | LMNA (0.48) | EGFRKMT2AMEN1KDM4ETSHR | |
| SCHEMBL28431351 | 0.63 | NTRK1 (0.54) | ALDH1A1KMT2AMEN1POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940840-A1 | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007045758-A1 | 6-HETEROARYLPYRIDOINDOLONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2007-04-26 | — | — | WO | disclosed |