Sugi Predict

Sugi Predict / Compounds / SCHEMBL476184

SCHEMBL476184

SCHEMBL476184

CCc1ccc(-c2csc(N)n2)cc1

nearest known ligand 0.68

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ LTA4H P09960 11/20 0.68
▸ ALDH1A1 P00352 6/20 0.59
▸ RAB9A P51151 5/20 0.59
▸ NPC1 O15118 4/20 0.59
▸ MAPT P10636 3/20 0.59
▸ SMN1; SMN2 Q16637 3/20 0.59
▸ KDM4E B2RXH2 2/20 0.59
▸ MEN1 O00255 1/20 0.59
▸ LMNA P02545 1/20 0.59
▸ NFKB1 P19838 1/20 0.59
▸ NFKB2 Q00653 1/20 0.59
▸ KMT2A Q03164 1/20 0.59
▸ RELA Q04206 1/20 0.59
▸ MKNK1 Q9BUB5 1/20 0.59
▸ MKNK2 Q9HBH9 1/20 0.59
▸ ALOX5 P09917 1/20 0.59
▸ POLB P06746 1/20 0.59
▸ CYP3A4 P08684 1/20 0.55
▸ NOS1 P29475 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3129405 0.86 LTA4H (0.64) LTA4HALDH1A1RAB9ANPC1MAPT
SCHEMBL1771825 0.84 ALDH1A1 (0.79) LTA4HALDH1A1RAB9ANPC1MAPT
SCHEMBL13825294 0.83 LTA4H (0.67) LTA4HALDH1A1RAB9ANPC1MAPT
SCHEMBL10087445 0.83 LTA4H (0.60) LTA4HALDH1A1RAB9ANPC1MAPT
SCHEMBL23610361 0.82 ALDH1A1 (0.83) LTA4HALDH1A1RAB9ANPC1MAPT
SCHEMBL12297161 0.81 GAA (0.57) LTA4HALDH1A1RAB9ANPC1MAPT
SCHEMBL19566850 0.81 RAB9A (0.49) LTA4HALDH1A1RAB9ANPC1MAPT
SCHEMBL11838315 0.81 LTA4H (0.62) LTA4HALDH1A1RAB9ANPC1MAPT
SCHEMBL474305 0.81 LTA4H (0.62) LTA4HALDH1A1RAB9ANPC1MAPT
SCHEMBL8146192 0.80 LTA4H (0.63) LTA4HALDH1A1RAB9ANPC1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3939968-A1 NOVEL COMPOUND HAVING ANTICANCER ACTIVITY, AND METHOD FOR PRODUCING SAME Medicinal Bioconvergence Research Center (KR) 2022-01-19 — — EP disclosed
US-8575178-B2 Isothiazolo-pyrimidinedione derivatives as TRPA1 modulators GLENMARK PHARMACEUTICALS S.A. (CH) 2013-11-05 — — US disclosed
US-8575178-B2 Isothiazolo-pyrimidinedione derivatives as TRPA1 modulators GLENMARK PHARMACEUTICALS S.A. (CH) 2013-11-05 — — US disclosed
US-8575178-B2 Isothiazolo-pyrimidinedione derivatives as TRPA1 modulators GLENMARK PHARMACEUTICALS S.A. (CH) 2013-11-05 — — US disclosed
EP-2411397-B1 ISOTHIAZOLO-PYRIMIDINEDIONE DERIVATIVES AS TRPA1 MODULATORS GLENMARK PHARMACEUTICALS SA (CH) 2013-05-29 — — EP disclosed
CN-102395592-A Isothiazolopyrimidinedione derivatives as TRPA1 modulators GLENMARK PHARMACEUTICALS SA 2012-03-28 — — CN disclosed
EP-2411397-A1 ISOTHIAZOLO-PYRIMIDINEDIONE DERIVATIVES AS TRPA1 MODULATORS Glenmark Pharmaceuticals S.A. (CH) 2012-02-01 — — EP disclosed
US-20120010223-A1 ISOTHIAZOLO-PYRIMIDINEDIONE DERIVATIVES AS TRPAI MODULATORS GLENMARK PHARMACEUTICALS, S.A. (CH) 2012-01-12 — — US disclosed
US-20120010223-A1 ISOTHIAZOLO-PYRIMIDINEDIONE DERIVATIVES AS TRPAI MODULATORS GLENMARK PHARMACEUTICALS, S.A. (CH) 2012-01-12 — — US disclosed
US-20120010223-A1 ISOTHIAZOLO-PYRIMIDINEDIONE DERIVATIVES AS TRPAI MODULATORS GLENMARK PHARMACEUTICALS, S.A. (CH) 2012-01-12 — — US disclosed
US-20090325987-A1 QUINAZOLINEDIONE DERIVATIVES AS TRPA1 MODULATORS GLENMARK PHARMACEUTICALS, S.A. (CH) 2009-12-31 — — US disclosed
US-7595398-B2 N-(5-membered aromatic ring)-amido anti-viral compounds SMITHKLINE BEECHAM CORPORATION (US) 2009-09-29 — — US disclosed
CN-101331125-A N-(5-membered aromatic ring)-amido anti-viral compounds GENELABS TECH INC (US) 2008-12-24 — — CN disclosed
EP-1971597-A2 N-(5-MEMBERED HETEROAROMATIC RING)-AMIDO ANTI-VIRAL COMPOUNDS GENELABS TECHNOLOGIES, INC. (US) 2008-09-24 — — EP disclosed
US-20070265265-A1 N-(5-MEMBERED AROMATIC RING)-AMIDO ANTI-VIRAL COMPOUNDS GENELABS TECHNOLOGIES, INC. 2007-11-15 — — US disclosed
WO-2007070600-A2 N-(5-MEMBERED HETEROAROMATIC RING)-AMIDO ANTI-VIRAL COMPOUNDS GENELABS TECHNOLOGIES, INC. (US) 2007-06-21 — — WO disclosed
CN-1440383-A PPAR gamma modulators SANKYO CO (JP) 2003-09-03 — — CN disclosed
US-20030134859-A1 PPAR-gamma modulator SANKYO COMPANY, LIMITED (JP) 2003-07-17 — — US disclosed
EP-1277729-A1 PPAR (GAMMA) MODULATORS Sankyo Company, Limited (JP) 2003-01-22 — — EP disclosed
US-4237136-A IMMUNOSTIMULANTS GRUNENTHAL GMBH (DE) 1980-12-02 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120010223-A1 ISOTHIAZOLO-PYRIMIDINEDIONE DERIVATIVES AS TRPAI MODULATORS TRPA1, TRPV1, TRPC3 LTA4H 423/4885ALDH1A1 721/4885RAB9A 2273/4885
US-20030134859-A1 PPAR-gamma modulator PPARG, PPARA, PPARD LTA4H 2927/4885ALDH1A1 583/4885RAB9A 1179/4885
US-20090325987-A1 QUINAZOLINEDIONE DERIVATIVES AS TRPA1 MODULATORS TRPA1, TRPV1, TRPC3 LTA4H 564/4885ALDH1A1 871/4885RAB9A 2497/4885
US-20070265265-A1 N-(5-MEMBERED AROMATIC RING)-AMIDO ANTI-VIRAL COMPOUNDS ZC3HAV1, ZC3HAV1L, HAVCR2 LTA4H 4415/4885ALDH1A1 4423/4885RAB9A 487/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.