SCHEMBL4762902

SCHEMBL4762902

Clc1ccc(N(c2ccccc2)N2CCCC2)cc1Cl

nearest known ligand 0.39

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
UTS2R Q9UKP6 9/20 0.39
OPRK1 P41145 8/20 0.39
CYP3A4 P08684 4/20 0.39
CYP2D6 P10635 4/20 0.39
SIGMAR1 Q99720 2/20 0.39
CHRM2 P08172 1/20 0.37
CHRM3 P20309 1/20 0.37
POLB P06746 2/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
HPGD P15428 2/20 0.36
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
GAA P10253 1/20 0.35
HTT P42858 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27544631 0.82 HPGD (0.41) CYP3A4CYP2D6SIGMAR1POLBSMN1; SMN2
SCHEMBL1933552 0.80 ALDH1A1 (0.42) CYP3A4CYP2D6SIGMAR1POLBSMN1; SMN2
SCHEMBL11820260 0.78 ALDH1A1 (0.44) CYP3A4CYP2D6SIGMAR1POLBSMN1; SMN2
SCHEMBL6734448 0.74 ALDH1A1 (0.36) CHRM2CHRM3POLBSMN1; SMN2HPGD
SCHEMBL473405 0.65 ALDH1A1 (0.40) CYP3A4CYP2D6SIGMAR1POLBSMN1; SMN2
SCHEMBL2091976 0.63 NPSR1 (0.47) CHRM2CHRM3POLBMEN1KMT2A
SCHEMBL11771602 0.63 ADORA3 (0.37) UTS2ROPRK1CYP3A4CYP2D6CHRM2
SCHEMBL9864709 0.62 CTSK (0.38) CYP3A4CYP2D6POLBSMN1; SMN2MEN1
SCHEMBL11035980 0.62 ALDH1A1 (0.37) CYP3A4CYP2D6POLBSMN1; SMN2MEN1
SCHEMBL2091974 0.62 NPSR1 (0.45) CHRM2CHRM3POLBKMT2AGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1881975-A1 N,N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2008-01-30 EP disclosed
WO-2006121218-A1 N,N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2006-11-16 WO disclosed