Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.42 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8245894 | 0.89 | POLB (0.47) | POLBSMN1; SMN2MAPTHTTENPP2 | |
| SCHEMBL4761009 | 0.85 | MEN1 (0.56) | POLBSMN1; SMN2MAPTCYP3A4GAA | |
| SCHEMBL4762716 | 0.85 | SMN1; SMN2 (0.51) | POLBSMN1; SMN2MAPTCYP3A4GAA | |
| SCHEMBL4762664 | 0.84 | POLB (0.56) | POLBMAPTENPP2SLC6A7MEN1 | |
| SCHEMBL4761369 | 0.84 | POLB (0.52) | POLBMAPTENPP2SLC6A7MEN1 | |
| SCHEMBL4762542 | 0.83 | HSD11B1 (0.53) | SMN1; SMN2MAPTCYP3A4GAACYP2C9 | |
| SCHEMBL4763187 | 0.82 | SMN1; SMN2 (0.55) | SMN1; SMN2MAPTHTTKDM4ESLC6A7 | |
| SCHEMBL4764201 | 0.81 | POLB (0.49) | POLBMAPTGAAKDM4ESLC6A7 | |
| SCHEMBL4761689 | 0.81 | POLB (0.52) | POLBMAPTGAANPSR1KDM4E | |
| SCHEMBL8246475 | 0.81 | ALDH1A1 (0.58) | POLBSMN1; SMN2MAPTGAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007009635-A1 | PHENYL SUBSTITUTED PIPERAZINE-DERIVATIVES AS INHIBITORS OF PLAMINOGENIC ACTIVATOR INHIBITORS-I (PAI-I) | BAYER HEALTHCARE AG (DE) | 2007-01-25 | — | — | WO | disclosed |