Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 13/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 13/20 | 0.38 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | GHSR | Q92847 | 1/20 | 0.34 |
| ▸ | UBE2M | P61081 | 2/20 | 0.33 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4765027 | 0.84 | CTSD (0.45) | CTSDSLC6A2SLC6A4SLC18A3SLC6A3 | |
| SCHEMBL6214947 | 0.76 | CTSD (0.37) | CTSDSLC6A2SLC6A4SLC6A3MEN1 | |
| SCHEMBL4763254 | 0.75 | CTSD (0.38) | CTSDSLC6A2SLC6A4SLC18A3SLC6A3 | |
| SCHEMBL4763258 | 0.75 | CTSD (0.38) | CTSDSLC6A2SLC6A4SLC18A3SLC6A3 | |
| SCHEMBL3956518 | 0.72 | CYP2C9 (0.33) | CYP2D6ALDH1A1 | |
| SCHEMBL2776534 | 0.72 | CTSD (0.55) | CTSDSLC6A2SLC6A4SLC18A3SLC6A3 | |
| SCHEMBL2776529 | 0.72 | CTSD (0.55) | CTSDSLC6A2SLC6A4SLC18A3SLC6A3 | |
| SCHEMBL4765023 | 0.71 | CTSD (0.38) | CTSDSLC6A2SLC6A4SLC18A3SLC6A3 | |
| SCHEMBL7427599 | 0.70 | MEN1 (0.46) | MEN1KMT2AALDH1A1HTT | |
| SCHEMBL5143426 | 0.69 | CTSD (0.55) | CTSDSLC6A2SLC6A4SLC6A3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1320370-A4 | METHOD OF TREATMENT | SMITHKLINE BEECHAM CORP (US) | 2008-10-22 | — | — | EP | disclosed |
| EP-1307204-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2004-06-02 | — | — | EP | disclosed |
| EP-1320370-A1 | METHOD OF TREATMENT | SmithKline Beecham Corporation (US) | 2003-06-25 | — | — | EP | disclosed |
| EP-1307204-A1 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2003-05-07 | — | — | EP | disclosed |
| WO-2002017924-A1 | METHOD OF TREATMENT | SMITHKLINE BEECHAM CORPORATION (GB) | 2002-03-07 | — | — | WO | disclosed |
| WO-2001095911-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-12-20 | — | — | WO | disclosed |