Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 4/20 | 0.35 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.34 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.34 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL476394 | 0.89 | HTR2C (0.37) | APLNRNAMPT | |
| SCHEMBL3702686 | 0.88 | HTR6 (0.40) | — | |
| SCHEMBL4126123 | 0.88 | NAMPT (0.35) | NAMPTPTGDR2 | |
| SCHEMBL476395 | 0.88 | NAMPT (0.33) | APLNRNAMPTGLO1SLC40A1CXCR3 | |
| SCHEMBL476470 | 0.88 | HTR6 (0.36) | NAMPTSLC40A1 | |
| SCHEMBL18258907 | 0.87 | HTR6 (0.32) | NAMPT | |
| SCHEMBL3705663 | 0.86 | DPP4 (0.37) | KCNA5 | |
| SCHEMBL3707637 | 0.86 | SLC16A3 (0.37) | KCNA5 | |
| SCHEMBL4125764 | 0.85 | NFE2L2 (0.40) | NAMPTGLO1SLC40A1 | |
| SCHEMBL476373 | 0.85 | GLO1 (0.39) | APLNRNAMPTGLO1SLC40A1NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2412713-B1 | PYRAZOLE COMPOUND | TAKEDA PHARMACEUTICAL (JP) | 2016-11-30 | — | — | EP | disclosed |
| EP-2412713-A1 | PYRAZOLE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2012-02-01 | — | — | EP | disclosed |