Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.36 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.33 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.32 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.32 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.32 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.32 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.32 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.32 |
| ▸ | ALKBH2 | Q6NS38 | 1/20 | 0.32 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.32 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3702686 | 0.92 | HTR6 (0.40) | HTR6HTR2AHTR2CHTR7 | |
| SCHEMBL4126123 | 0.91 | NAMPT (0.35) | HTR6GRM1HRH1GRM5TMEM97 | |
| SCHEMBL18258907 | 0.90 | HTR6 (0.32) | HTR6NAMPTHTR2AHTR2CHTR7 | |
| SCHEMBL4125764 | 0.88 | NFE2L2 (0.40) | TAS2R14NAMPTSLC40A1 | |
| SCHEMBL476414 | 0.88 | HTR2C (0.39) | HTR6GRM1HRH1GRM5TMEM97 | |
| SCHEMBL476388 | 0.88 | PKM (0.38) | HTR6LIMK2KMT2AL3MBTL1 | |
| SCHEMBL476365 | 0.88 | APLNR (0.35) | NAMPTSLC40A1 | |
| SCHEMBL476415 | 0.87 | HTR6 (0.35) | HTR6GRM1HRH1GRM5TMEM97 | |
| SCHEMBL476363 | 0.86 | HTR6 (0.39) | HTR6GRM4NAMPTHTR2AHTR2C | |
| SCHEMBL476471 | 0.84 | NAMPT (0.35) | HTR6GRM4NAMPTALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2412713-B1 | PYRAZOLE COMPOUND | TAKEDA PHARMACEUTICAL (JP) | 2016-11-30 | — | — | EP | disclosed |
| EP-2412713-A1 | PYRAZOLE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2012-02-01 | — | — | EP | disclosed |