Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | VCAM1 | P19320 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | GALR3 | O60755 | 1/20 | 0.37 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9725444 | 0.75 | PIK3CD (0.47) | ALDH1A1KDM4EHTTHCAR3SMN1; SMN2 | |
| SCHEMBL6013576 | 0.74 | ALDH1A1 (0.43) | ALDH1A1KDM4EHCAR3KMT2AMEN1 | |
| SCHEMBL9725432 | 0.74 | SMN1; SMN2 (0.61) | ALDH1A1KDM4EHTTHCAR3SMN1; SMN2 | |
| SCHEMBL9980399 | 0.72 | ALDH1A1 (0.59) | ALDH1A1KDM4EHTTHCAR3SMN1; SMN2 | |
| SCHEMBL9725472 | 0.71 | TSHR (0.47) | ALDH1A1KDM4EHTTHCAR3GAA | |
| SCHEMBL3999307 | 0.68 | VCAM1 (0.68) | ALDH1A1VCAM1 | |
| SCHEMBL1959419 | 0.68 | SMN1; SMN2 (0.62) | ALDH1A1KDM4EHTTHCAR3SMN1; SMN2 | |
| SCHEMBL9725392 | 0.68 | MAPT (0.46) | ALDH1A1KDM4ESMN1; SMN2LMNAGAA | |
| SCHEMBL20642265 | 0.67 | CA1 (0.52) | ALDH1A1KDM4EHTTHCAR3LMNA | |
| SCHEMBL3999400 | 0.67 | ALDH1A1 (0.45) | ALDH1A1HTTSMN1; SMN2LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809607-B1 | SULFONYL BENZIMIDAZOLE DERIVATIVES | PFIZER (US) | 2008-12-17 | — | — | EP | disclosed |