Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.46 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.46 |
| ▸ | CPT1A | P50416 | 1/20 | 0.45 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.41 |
| ▸ | ACLY | P53396 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPY2R | P49146 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4772836 | 0.87 | ALDH1A1 (0.51) | L3MBTL1HSD17B1HSD17B2CPT1ACPT1B | |
| SCHEMBL27755052 | 0.76 | ACLY (0.54) | HSD17B1HSD17B2ALDH1A1HPGDHSD17B10 | |
| SCHEMBL8365787 | 0.71 | NPSR1 (0.53) | ALDH1A1MEN1KMT2AKDM4ENPSR1 | |
| SCHEMBL3053031 | 0.70 | HSD17B1 (0.45) | HSD17B1HSD17B2ALDH1A1HPGDHSD17B10 | |
| SCHEMBL18352413 | 0.68 | FFAR1 (0.59) | ALDH1A1MEN1KMT2ANPSR1MAPT | |
| SCHEMBL4764323 | 0.68 | CA12 (0.40) | HSD17B1HSD17B2ALDH1A1KDM4ENPSR1 | |
| SCHEMBL27755319 | 0.68 | HSD17B1 (0.48) | HSD17B1HSD17B2ALDH1A1HPGDHSD17B10 | |
| SCHEMBL31689801 | 0.68 | NPSR1 (0.68) | L3MBTL1MEN1KMT2ANPSR1POLB | |
| SCHEMBL324789 | 0.68 | NPSR1 (0.68) | L3MBTL1MEN1KMT2ANPSR1POLB | |
| SCHEMBL24543280 | 0.67 | PPARG (0.52) | ACLYMEN1KMT2ANPSR1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572678-A4 | SUBSTITUTED N-PHENYL SULFONAMIDE BRADYKININ ANTAGONISTS | ELAN PHARM INC (US) | 2008-05-07 | — | — | EP | disclosed |
| EP-1572678-A2 | SUBSTITUTED N-PHENYL SULFONAMIDE BRADYKININ ANTAGONISTS | Elan Pharmaceuticals, Inc. (US) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004056319-A2 | SUBSTITUTED N-PHENYL SULFONAMIDE BRADYKININ ANTAGONISTS | ELAN PHARMACEUTICALS INC. (US) | 2004-07-08 | — | — | WO | disclosed |