Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.49 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.49 |
| ▸ | SLC16A3 | O15427 | 3/20 | 0.48 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | CPT1A | P50416 | 1/20 | 0.46 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | G6PD | P11413 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4764324 | 0.87 | L3MBTL1 (0.46) | ALDH1A1HPGDHSD17B10HSD17B1HSD17B2 | |
| SCHEMBL27755052 | 0.76 | ACLY (0.54) | ALDH1A1HPGDHSD17B10HSD17B1HSD17B2 | |
| SCHEMBL4764323 | 0.76 | CA12 (0.40) | ALDH1A1HSD17B1HSD17B2LMNAPOLB | |
| SCHEMBL3897238 | 0.76 | KEAP1 (0.55) | ALDH1A1SLC16A3HKDC1KMT2AMAPT | |
| SCHEMBL3053031 | 0.75 | HSD17B1 (0.45) | ALDH1A1HPGDHSD17B10HSD17B1HSD17B2 | |
| SCHEMBL4766076 | 0.74 | PTGES2 (0.55) | ALDH1A1SLC16A3 | |
| SCHEMBL34473852 | 0.73 | ALDH1A1 (0.78) | ALDH1A1HPGDHSD17B10MEN1LMNA | |
| SCHEMBL27775534 | 0.72 | ACLY (0.68) | ALDH1A1HPGDHSD17B10MCL1 | |
| SCHEMBL34462608 | 0.72 | HSD17B1 (0.44) | ALDH1A1HPGDHSD17B10HSD17B1HSD17B2 | |
| SCHEMBL3056165 | 0.72 | HSD17B1 (0.47) | ALDH1A1HPGDHSD17B10HSD17B1HSD17B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572678-A4 | SUBSTITUTED N-PHENYL SULFONAMIDE BRADYKININ ANTAGONISTS | ELAN PHARM INC (US) | 2008-05-07 | — | — | EP | disclosed |
| EP-1572678-A2 | SUBSTITUTED N-PHENYL SULFONAMIDE BRADYKININ ANTAGONISTS | Elan Pharmaceuticals, Inc. (US) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004056319-A2 | SUBSTITUTED N-PHENYL SULFONAMIDE BRADYKININ ANTAGONISTS | ELAN PHARMACEUTICALS INC. (US) | 2004-07-08 | — | — | WO | disclosed |