Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 14/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.44 |
| ▸ | HMGCR | P04035 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1534985 | 0.86 | ACHE (0.53) | ACHEEPHX2EPHX1 | |
| SCHEMBL6201757 | 0.83 | ACHE (0.50) | ACHEEPHX2EPHX1 | |
| SCHEMBL8909168 | 0.77 | ACHE (0.53) | ACHEEPHX1 | |
| SCHEMBL3956624 | 0.77 | ACHE (0.53) | ACHEEPHX1 | |
| SCHEMBL7397655 | 0.76 | ACHE (0.47) | ACHEEPHX2EPHX1 | |
| SCHEMBL2374951 | 0.75 | HMGCR (0.50) | HMGCRCHRM1TBXA2RADRA1AEPHX1 | |
| SCHEMBL1536313 | 0.75 | HMGCR (0.50) | HMGCRCHRM1TBXA2RADRA1AEPHX1 | |
| SCHEMBL461365 | 0.74 | ACHE (0.58) | ACHEEPHX2EPHX1 | |
| SCHEMBL856208 | 0.74 | ACHE (0.50) | ACHEEPHX1 | |
| SCHEMBL7048610 | 0.74 | ACHE (0.50) | ACHEEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2928867-A1 | PYRIDINE-2-AMIDES USEFUL AS CB2 AGONISTS | F. Hoffmann-La Roche AG (CH) | 2015-10-14 | — | — | EP | disclosed |
| WO-2014086805-A1 | PYRIDINE-2-AMIDES USEFUL AS CB2 AGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2014-06-12 | — | — | WO | disclosed |
| EP-1505963-A4 | HEPATITIS C VIRUS INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2008-12-24 | — | — | EP | disclosed |
| EP-1505963-A1 | HEPATITIS C VIRUS INHIBITORS | Bristol-Myers Squibb Company (US) | 2005-02-16 | — | — | EP | disclosed |
| WO-2003099274-A1 | HEPATITIS C VIRUS INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-12-04 | — | — | WO | disclosed |