Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ITGAV | P06756 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 3/20 | 0.37 |
| ▸ | PPARD | Q03181 | 3/20 | 0.37 |
| ▸ | PPARA | Q07869 | 3/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | MMP12 | P39900 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20534707 | 0.75 | MEN1 (0.48) | MEN1KMT2APPARGPPARAALDH1A1 | |
| SCHEMBL4773131 | 0.75 | S1PR1 (0.39) | MCOLN3ALDH1A1KDM4ELMNA | |
| SCHEMBL15302655 | 0.71 | MMP2 (0.45) | PPARGPPARAMMP2MMP9MMP12 | |
| SCHEMBL4767312 | 0.70 | MCOLN3 (0.55) | MCOLN3MEN1KMT2APPARGPPARA | |
| SCHEMBL4027618 | 0.68 | MCOLN3 (0.54) | MCOLN3KMT2AITGAVHSD11B1ALDH1A1 | |
| SCHEMBL10895395 | 0.67 | MEN1 (0.46) | MEN1KMT2APPARGPPARAALDH1A1 | |
| SCHEMBL12010352 | 0.67 | MCOLN3 (0.56) | MCOLN3MEN1KMT2AHSD11B1ESR1 | |
| SCHEMBL8148464 | 0.67 | MMP2 (0.40) | MMP2MMP9MMP12ALDH1A1LMNA | |
| SCHEMBL6184837 | 0.67 | MCOLN3 (0.56) | MCOLN3ITGAVPGRHSD11B1ALDH1A1 | |
| SCHEMBL6909558 | 0.66 | MEN1 (0.63) | MEN1KMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572678-A4 | SUBSTITUTED N-PHENYL SULFONAMIDE BRADYKININ ANTAGONISTS | ELAN PHARM INC (US) | 2008-05-07 | — | — | EP | disclosed |
| EP-1572678-A2 | SUBSTITUTED N-PHENYL SULFONAMIDE BRADYKININ ANTAGONISTS | Elan Pharmaceuticals, Inc. (US) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004056319-A2 | SUBSTITUTED N-PHENYL SULFONAMIDE BRADYKININ ANTAGONISTS | ELAN PHARMACEUTICALS INC. (US) | 2004-07-08 | — | — | WO | disclosed |