Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 7/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD5 | P21918 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | CA9 | Q16790 | 2/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.32 |
| ▸ | DHFR | P00374 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4768850 | 0.84 | SLC18A3 (0.40) | DRD2OPRM1KCNH2HRH3 | |
| SCHEMBL15652124 | 0.81 | HTR1D (0.34) | — | |
| SCHEMBL4765378 | 0.79 | ADRA2C (0.41) | DRD2SIGMAR1KCNH2HRH3DRD1 | |
| SCHEMBL328311 | 0.73 | QDPR (0.53) | DRD2SIGMAR1DRD1 | |
| SCHEMBL27682140 | 0.72 | DDB1 (0.41) | DDB1CRBNDRD2SIGMAR1DRD1 | |
| SCHEMBL4572968 | 0.71 | DRD2 (0.43) | DDB1CRBNDRD2SIGMAR1DRD1 | |
| SCHEMBL3531340 | 0.70 | TLR9 (0.47) | OPRM1HRH3 | |
| SCHEMBL273350 | 0.70 | CYP3A4 (0.50) | DDB1CRBNCA1CA2CA9 | |
| SCHEMBL29411064 | 0.70 | CYP3A4 (0.50) | DDB1CRBNCA1CA2CA9 | |
| SCHEMBL2651932 | 0.70 | QDPR (0.60) | SIGMAR1KCNH2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937681-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007033232-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-03-22 | — | — | WO | disclosed |