Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | QDPR | P09417 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 5/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | HTR6 | P50406 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | TAF1 | P21675 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | HTR1B | P28222 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD5 | P21918 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4769338 | 0.84 | SLC18A3 (0.40) | ADRA2CQDPRDRD2KCNH2HRH3 | |
| SCHEMBL328311 | 0.81 | QDPR (0.53) | ADRA2CQDPRDRD1DRD2SIGMAR1 | |
| SCHEMBL4764932 | 0.79 | DDB1 (0.34) | DRD1DRD2SIGMAR1DRD3KCNH2 | |
| SCHEMBL10127720 | 0.73 | GRIN2B (0.48) | ADRA2CQDPRTAF1HTR1DHTR1B | |
| SCHEMBL27682140 | 0.72 | DDB1 (0.41) | DRD1DRD2SIGMAR1DRD3DRD4 | |
| SCHEMBL3530693 | 0.71 | TLR9 (0.48) | ADRA2CDRD2DRD3DRD4FAAH | |
| SCHEMBL4572968 | 0.70 | DRD2 (0.43) | DRD1DRD2SIGMAR1DRD3DRD4 | |
| SCHEMBL19953550 | 0.70 | ADRA2C (0.47) | ADRA2CDRD1DRD3KCNH2HRH3 | |
| SCHEMBL273350 | 0.69 | CYP3A4 (0.50) | CA1CA2CA9CA14 | |
| SCHEMBL29411064 | 0.69 | CYP3A4 (0.50) | CA1CA2CA9CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937681-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007033232-A1 | 5-OXO-5,8-DIHYDRO-PYRIDO-PYRIMIDINES AS INHIBITORS OF C-FMS KINASE | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-03-22 | — | — | WO | disclosed |