Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 7/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | PDE5A | O76074 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | MAOA | P21397 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2831517 | 1.00 | ESR2 (0.39) | ESR2LMNAESR1ALDH1A1PDE5A | |
| SCHEMBL310810 | 0.82 | GPR119 (0.37) | ESR2LMNAPDE5AMAOAMAOB | |
| SCHEMBL1104538 | 0.82 | GPR119 (0.37) | ESR2LMNAPDE5AMAOAMAOB | |
| SCHEMBL2832438 | 0.81 | KCNH2 (0.51) | LMNAALDH1A1KDM4EMAOB | |
| SCHEMBL839486 | 0.80 | PDE5A (0.36) | ESR2LMNAESR1ALDH1A1PDE5A | |
| SCHEMBL2832873 | 0.77 | KCNH2 (0.59) | MAOB | |
| SCHEMBL29388249 | 0.73 | GPR119 (0.38) | ESR2LMNAESR1PDE5A | |
| SCHEMBL310811 | 0.71 | PDE5A (0.36) | ESR2LMNAESR1ALDH1A1PDE5A | |
| SCHEMBL2835707 | 0.70 | ESR2 (0.35) | ESR2LMNAESR1HSD17B10MAPT | |
| SCHEMBL25354757 | 0.70 | LMNA (0.41) | ESR2LMNAESR1ALDH1A1PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934176-A1 | QUATERNARY ALPHA-AMINOCARBOXAMIDE DERIVATIVES AS MODULATORS OF VOLTAGE-GATED SODIUM CHANNELS | GLAXO GROUP LIMITED (GB) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007042240-A1 | QUATERNARY ALPHA-AMINOCARBOXAMIDE DERIVATIVES AS MODULATORS OF VOLTAGE-GATED SODIUM CHANNELS | GLAXO GROUP LIMITED (GB) | 2007-04-19 | — | — | WO | disclosed |