Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 7/20 | 0.39 |
| ▸ | JUN | P05412 | 5/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 5/20 | 0.39 |
| ▸ | RELA | Q04206 | 5/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | XPO1 | O14980 | 3/20 | 0.36 |
| ▸ | ATF1 | P18846 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 2/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4772564 | 0.83 | POLB (0.34) | NFKB1JUNNFKB2RELAPOLB | |
| SCHEMBL6487618 | 0.80 | JAK2 (0.38) | NFKB1JUNNFKB2RELAPOLB | |
| SCHEMBL4769009 | 0.80 | NFKB1 (0.40) | NFKB1JUNNFKB2RELAPOLB | |
| SCHEMBL4775431 | 0.79 | SLC9A5 (0.38) | NFKB1JUNNFKB2RELAPOLB | |
| SCHEMBL4772148 | 0.79 | POLB (0.35) | NFKB1JUNNFKB2RELAPOLB | |
| SCHEMBL4768927 | 0.78 | NFKB1 (0.37) | NFKB1JUNNFKB2RELAPOLB | |
| SCHEMBL4768472 | 0.78 | NFKB1 (0.52) | NFKB1JUNNFKB2RELAPOLB | |
| SCHEMBL4770177 | 0.77 | POLB (0.33) | NFKB1JUNNFKB2RELAPOLB | |
| SCHEMBL4774497 | 0.77 | NFKB1 (0.40) | NFKB1JUNNFKB2RELAPOLB | |
| SCHEMBL5723638 | 0.77 | NFKB1 (0.39) | NFKB1JUNNFKB2RELAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303496-B9 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| EP-1303496-B1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-12 | — | — | EP | disclosed |
| US-6908920-B2 | Pyrimidine derivatives | ASTRAZENECA AB (SE) | 2005-06-21 | — | — | US | disclosed |