Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC9A5 | Q14940 | 1/20 | 0.38 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.37 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 6/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.36 |
| ▸ | ATF1 | P18846 | 2/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | GBA1 | P04062 | 1/20 | 0.34 |
| ▸ | JUN | P05412 | 2/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.33 |
| ▸ | RELA | Q04206 | 2/20 | 0.33 |
| ▸ | HPGDS | O60760 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4770177 | 0.84 | POLB (0.33) | NFKB1ATF1LRRK2POLBAPEX1 | |
| SCHEMBL4769009 | 0.82 | NFKB1 (0.40) | NFKB1ATF1LRRK2POLBAPEX1 | |
| SCHEMBL4772148 | 0.81 | POLB (0.35) | NFKB1ATF1LRRK2POLBAPEX1 | |
| SCHEMBL4768927 | 0.81 | NFKB1 (0.37) | NFKB1ATF1LRRK2POLBAPEX1 | |
| SCHEMBL4765263 | 0.79 | NFKB1 (0.39) | NFKB1ATF1LRRK2POLBAPEX1 | |
| SCHEMBL5723806 | 0.78 | NFKB1 (0.39) | NFKB1ATF1LRRK2POLBAPEX1 | |
| SCHEMBL4768852 | 0.76 | ALDH1A1 (0.46) | NFKB1ATF1LRRK2POLBAPEX1 | |
| SCHEMBL4772564 | 0.75 | POLB (0.34) | NFKB1ATF1LRRK2POLBAPEX1 | |
| SCHEMBL5723265 | 0.75 | NFKB1 (0.37) | NFKB1ATF1LRRK2POLBAPEX1 | |
| SCHEMBL5723255 | 0.74 | NFKB1 (0.44) | NFKB1ATF1LRRK2POLBAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303496-B9 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| EP-1303496-B1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-12 | — | — | EP | disclosed |