Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 15/20 | 0.40 |
| ▸ | JUN | P05412 | 7/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 7/20 | 0.40 |
| ▸ | RELA | Q04206 | 7/20 | 0.40 |
| ▸ | XPO1 | O14980 | 4/20 | 0.40 |
| ▸ | ATF1 | P18846 | 9/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4775431 | 0.82 | SLC9A5 (0.38) | NFKB1JUNNFKB2RELAATF1 | |
| SCHEMBL4772148 | 0.82 | POLB (0.35) | NFKB1JUNNFKB2RELAXPO1 | |
| SCHEMBL4770177 | 0.80 | POLB (0.33) | NFKB1JUNNFKB2RELAXPO1 | |
| SCHEMBL4765263 | 0.80 | NFKB1 (0.39) | NFKB1JUNNFKB2RELAXPO1 | |
| SCHEMBL4768927 | 0.79 | NFKB1 (0.37) | NFKB1JUNNFKB2RELAXPO1 | |
| SCHEMBL4773876 | 0.75 | NFKB1 (0.40) | NFKB1JUNNFKB2RELAXPO1 | |
| SCHEMBL4768472 | 0.74 | NFKB1 (0.52) | NFKB1JUNNFKB2RELAXPO1 | |
| SCHEMBL4772564 | 0.74 | POLB (0.34) | NFKB1JUNNFKB2RELAXPO1 | |
| SCHEMBL6487618 | 0.71 | JAK2 (0.38) | NFKB1JUNNFKB2RELAXPO1 | |
| SCHEMBL4763606 | 0.71 | STK17B (0.41) | NFKB1JUNNFKB2RELAATF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303496-B9 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| EP-1303496-B1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-12 | — | — | EP | disclosed |