Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 6/20 | 0.35 |
| ▸ | JUN | P05412 | 3/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.35 |
| ▸ | RELA | Q04206 | 3/20 | 0.35 |
| ▸ | ATF1 | P18846 | 3/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4772643 | 0.83 | TYRO3 (0.42) | JAK2 | |
| SCHEMBL4765263 | 0.80 | NFKB1 (0.39) | LMNANFKB1JUNNFKB2RELA | |
| SCHEMBL4764083 | 0.74 | KMT2A (0.53) | LMNALCKMEN1KMT2AALDH1A1 | |
| SCHEMBL4769009 | 0.71 | NFKB1 (0.40) | NFKB1JUNNFKB2RELAATF1 | |
| SCHEMBL4765205 | 0.71 | CCNA2 (0.51) | LMNAMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL28526131 | 0.71 | OPRK1 (0.35) | NFKB1ATF1MEN1KMT2AALDH1A1 | |
| SCHEMBL4772148 | 0.70 | POLB (0.35) | NFKB1JUNNFKB2RELAATF1 | |
| SCHEMBL4775431 | 0.70 | SLC9A5 (0.38) | NFKB1JUNNFKB2RELAATF1 | |
| SCHEMBL28526521 | 0.70 | ALDH1A1 (0.34) | JAK2MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL28909314 | 0.70 | OPRK1 (0.38) | JAK2LMNANFKB1ATF1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6908920-B2 | Pyrimidine derivatives | ASTRAZENECA AB (SE) | 2005-06-21 | — | — | US | disclosed |