Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 7/20 | 0.44 |
| ▸ | VCP | P55072 | 3/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4770029 | 0.94 | SYK (0.44) | SYKVCPMAPK9MAPK10CHEK1 | |
| SCHEMBL4774864 | 0.88 | CHEK1 (0.50) | SYKMAPK9MAPK10CHEK1NTRK2 | |
| SCHEMBL4765275 | 0.86 | CHEK1 (0.43) | SYKMAPK9MAPK10CHEK1NTRK2 | |
| SCHEMBL4771624 | 0.81 | CHEK1 (0.46) | SYKMAPK9MAPK10CHEK1NTRK2 | |
| SCHEMBL4764815 | 0.81 | CHEK1 (0.49) | SYKMAPK9MAPK10CHEK1NTRK2 | |
| SCHEMBL4770076 | 0.81 | MAPK9 (0.45) | MAPK9MAPK10CHEK1NTRK2MAOA | |
| SCHEMBL4767407 | 0.80 | CHEK1 (0.43) | SYKMAPK9MAPK10CHEK1NTRK2 | |
| SCHEMBL4766694 | 0.80 | SYK (0.50) | SYKMAPK9CHEK1NTRK2MAPK8 | |
| SCHEMBL4775312 | 0.78 | GAA (0.43) | SYKMAPK9MAPK10CHEK1NTRK2 | |
| SCHEMBL4775386 | 0.78 | AURKA (0.49) | SYKMAPK9NTRK2FLT3MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581531-B1 | PYRIDINO¬2,3-D PYRIMIDINE DERIVATIVES AS SELECTIIVE KDR AND FGFR INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-02-27 | — | — | EP | claimed |