Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CCKAR | P32238 | 4/20 | 0.41 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4767501 | 0.93 | SMN1; SMN2 (0.42) | GAASMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL4774864 | 0.89 | CHEK1 (0.50) | GAASMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL4770076 | 0.84 | MAPK9 (0.45) | MEN1KMT2AALDH1A1CCKARMAPK9 | |
| SCHEMBL4764854 | 0.82 | CCKAR (0.45) | CCKAR | |
| SCHEMBL4771624 | 0.82 | CHEK1 (0.46) | MAPK9MAPK10SYKCHEK1NTRK2 | |
| SCHEMBL4764815 | 0.82 | CHEK1 (0.49) | MAPK9MAPK10SYKCHEK1NTRK2 | |
| SCHEMBL4765275 | 0.80 | CHEK1 (0.43) | MEN1KMT2AALDH1A1MAPK9MAPK10 | |
| SCHEMBL4766694 | 0.80 | SYK (0.50) | MAPK9SYKCHEK1NTRK2 | |
| SCHEMBL4765277 | 0.78 | SYK (0.44) | MAPK9MAPK10SYKCHEK1NTRK2 | |
| SCHEMBL4775386 | 0.77 | AURKA (0.49) | MAPK9SYKNTRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581531-B1 | PYRIDINO¬2,3-D PYRIMIDINE DERIVATIVES AS SELECTIIVE KDR AND FGFR INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-02-27 | — | — | EP | claimed |