Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MGAM | O43451 | 1/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.41 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL456000 | 0.82 | MEN1 (0.44) | MAPTSMN1; SMN2MEN1KMT2ANPSR1 | |
| SCHEMBL3635781 | 0.78 | HCAR3 (0.54) | SMN1; SMN2MEN1KMT2AHCAR3NPC1 | |
| SCHEMBL6606946 | 0.77 | ALDH1A1 (0.41) | MAPTSMN1; SMN2MEN1KMT2ANPSR1 | |
| SCHEMBL4756002 | 0.76 | ALDH1A1 (0.39) | MAPTSMN1; SMN2MEN1KMT2ANPSR1 | |
| SCHEMBL4704630 | 0.75 | ALDH1A1 (0.38) | MAPTSMN1; SMN2MEN1KMT2ANPSR1 | |
| SCHEMBL31132753 | 0.75 | ALDH1A1 (0.47) | MAPTMEN1KMT2AGAAKDM4E | |
| SCHEMBL476528 | 0.75 | ALDH1A1 (0.47) | MAPTMEN1KMT2AGAAKDM4E | |
| SCHEMBL21138873 | 0.73 | PTGS2 (0.53) | SMN1; SMN2MEN1KMT2APTGS2GAA | |
| SCHEMBL6385971 | 0.72 | ALDH1A1 (0.44) | MAPTSMN1; SMN2GAAALDH1A1 | |
| SCHEMBL9648858 | 0.71 | ALDH1A1 (0.43) | SMN1; SMN2MEN1KMT2AKDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2410857-A1 | P2X3, RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN | Merck Sharp & Dohme Corp. (US) | 2012-02-01 | — | — | EP | disclosed |
| WO-2010111058-A1 | P2X3, RECEPTOR ANTAGONISTS FOR TREATMENT OF PAIN | MERCK SHARP & DOHME CORP. (US) | 2010-09-30 | — | — | WO | disclosed |