Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 7/20 | 0.45 |
| ▸ | CTSL | P07711 | 6/20 | 0.45 |
| ▸ | CTSK | P43235 | 5/20 | 0.45 |
| ▸ | CTSB | P07858 | 3/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
| ▸ | ITGAV | P06756 | 1/20 | 0.35 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.35 |
| ▸ | CAPN1 | P07384 | 8/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | PREP | P48147 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4771026 | 0.93 | CTSL (0.49) | CTSSCTSLCTSKCTSBKCNA5 | |
| SCHEMBL4770318 | 0.93 | CTSL (0.47) | CTSSCTSLCTSKCTSBKCNA5 | |
| SCHEMBL4896763 | 0.86 | CTSL (0.56) | CTSSCTSLCTSKCTSB | |
| SCHEMBL4763182 | 0.86 | CTSK (0.45) | CTSSCTSLCTSKCTSB | |
| SCHEMBL5971256 | 0.85 | CTSK (0.55) | CTSSCTSLCTSKCTSB | |
| SCHEMBL4770696 | 0.80 | CTSL (0.47) | CTSSCTSLCTSKCTSBPREP | |
| SCHEMBL6593286 | 0.78 | CTSK (0.48) | CTSSCTSLCTSKCTSB | |
| SCHEMBL6206715 | 0.77 | CTSK (0.51) | CTSSCTSLCTSKCTSB | |
| SCHEMBL7006426 | 0.77 | CTSK (0.53) | CTSSCTSLCTSK | |
| SCHEMBL4762204 | 0.77 | CTSK (0.45) | CTSSCTSLCTSKCTSBPREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1320370-A4 | METHOD OF TREATMENT | SMITHKLINE BEECHAM CORP (US) | 2008-10-22 | — | — | EP | disclosed |
| EP-1320370-A1 | METHOD OF TREATMENT | SmithKline Beecham Corporation (US) | 2003-06-25 | — | — | EP | disclosed |
| EP-1158986-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2002-03-27 | — | — | EP | disclosed |
| WO-2002017924-A1 | METHOD OF TREATMENT | SMITHKLINE BEECHAM CORPORATION (GB) | 2002-03-07 | — | — | WO | disclosed |
| EP-1158986-A1 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000038687-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-07-06 | — | — | WO | disclosed |