Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 6/20 | 0.56 |
| ▸ | CTSS | P25774 | 6/20 | 0.56 |
| ▸ | CTSB | P07858 | 4/20 | 0.56 |
| ▸ | CTSK | P43235 | 4/20 | 0.43 |
| ▸ | TACR1 | P25103 | 4/20 | 0.36 |
| ▸ | CTSV | O60911 | 1/20 | 0.36 |
| ▸ | CCR3 | P51677 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.33 |
| ▸ | ALB | P02768 | 1/20 | 0.33 |
| ▸ | IL2 | P60568 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | CCKBR | P32239 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4771026 | 0.93 | CTSL (0.49) | CTSLCTSSCTSBCTSKTACR1 | |
| SCHEMBL4770318 | 0.93 | CTSL (0.47) | CTSLCTSSCTSBCTSKCTSV | |
| SCHEMBL4765723 | 0.86 | CTSS (0.45) | CTSLCTSSCTSBCTSK | |
| SCHEMBL4763182 | 0.82 | CTSK (0.45) | CTSLCTSSCTSBCTSKCCKBR | |
| SCHEMBL5971256 | 0.81 | CTSK (0.55) | CTSLCTSSCTSBCTSKCTSV | |
| SCHEMBL4765041 | 0.81 | CTSK (0.43) | CTSLCTSSCTSBCTSKCTSV | |
| SCHEMBL4770696 | 0.80 | CTSL (0.47) | CTSLCTSSCTSBCTSKCTSV | |
| SCHEMBL4766629 | 0.80 | CTSK (0.46) | CTSLCTSSCTSBCTSKCTSV | |
| SCHEMBL4762204 | 0.79 | CTSK (0.45) | CTSLCTSSCTSBCTSKCTSV | |
| SCHEMBL6593286 | 0.78 | CTSK (0.48) | CTSLCTSSCTSBCTSKCTSV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1320370-A4 | METHOD OF TREATMENT | SMITHKLINE BEECHAM CORP (US) | 2008-10-22 | — | — | EP | disclosed |
| EP-1320370-A1 | METHOD OF TREATMENT | SmithKline Beecham Corporation (US) | 2003-06-25 | — | — | EP | disclosed |
| WO-2002017924-A1 | METHOD OF TREATMENT | SMITHKLINE BEECHAM CORPORATION (GB) | 2002-03-07 | — | — | WO | disclosed |