Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | THRB | P10828 | 2/20 | 0.32 |
| ▸ | APEX1 | P27695 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | RECQL | P46063 | 2/20 | 0.32 |
| ▸ | GGPS1 | O95749 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14074156 | 0.79 | HPGD (0.63) | CYP3A4HPGDTDP1ALDH1A1HSD17B10 | |
| SCHEMBL2955866 | 0.78 | CHEK1 (0.46) | TDP1ALDH1A1LMNA | |
| SCHEMBL13177941 | 0.74 | CYP1A2 (0.46) | CYP3A4KDM4EPKMAPOBEC3AAPOBEC3G | |
| SCHEMBL2737196 | 0.73 | KDM4E (0.51) | LMNAKDM4EPKMAPOBEC3AAPOBEC3G | |
| SCHEMBL20123364 | 0.71 | ALDH1A1 (0.54) | CYP3A4HPGDTDP1ALDH1A1HSD17B10 | |
| SCHEMBL4765850 | 0.70 | MKNK1 (0.59) | CYP3A4HPGDTDP1ALDH1A1HSD17B10 | |
| SCHEMBL14350758 | 0.70 | HPGD (0.49) | CYP3A4HPGDTDP1ALDH1A1HSD17B10 | |
| SCHEMBL28333949 | 0.69 | LMNA (0.60) | ALDH1A1LMNAKDM4EPKMAPOBEC3A | |
| SCHEMBL12428994 | 0.69 | CHEK1 (0.45) | TDP1ALDH1A1LMNAMEN1KMT2A | |
| Bromide SCHEMBL10428847 | 0.67 | LMNA (0.58) | ALDH1A1LMNAKDM4EPKMAPOBEC3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120122840-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | MYREXIS, INC. (US) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122840-A1 | COMPOUNDS AND THERAPEUTIC USES THEREOF | VHL, TP53, ASAH2 | CYP3A4 2589/4885HPGD 415/4885TDP1 2000/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.