Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 3/20 | 0.45 |
| ▸ | CDK1 | P06493 | 4/20 | 0.45 |
| ▸ | KDR | P35968 | 3/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.45 |
| ▸ | CDK2 | P24941 | 7/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.44 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.43 |
| ▸ | MARK3 | P27448 | 1/20 | 0.42 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4769260 | 0.94 | CA2 (0.48) | AURKACA2CA1CA9SYK | |
| SCHEMBL4774317 | 0.92 | AURKA (0.53) | AURKACA2SYKCDK1KDR | |
| SCHEMBL4772582 | 0.90 | AURKA (0.52) | AURKACA2SYKCDK1KDR | |
| SCHEMBL4766388 | 0.86 | AURKA (0.49) | AURKACA2SYKCDK1KDR | |
| SCHEMBL4766530 | 0.85 | AURKA (0.55) | AURKASYKCDK1KDRCDK2 | |
| SCHEMBL4774057 | 0.84 | PRKCQ (0.56) | AURKASYKCDK1KDRPTK2 | |
| SCHEMBL4763724 | 0.84 | CA2 (0.47) | AURKACA2CA1CA9SYK | |
| SCHEMBL1936209 | 0.83 | KDR (0.56) | AURKASYKCDK1KDRPTK2 | |
| SCHEMBL4768983 | 0.83 | AURKA (0.53) | AURKACA2SYKCDK1KDR | |
| SCHEMBL4773980 | 0.82 | AURKA (0.52) | AURKACA2SYKCDK1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303496-B9 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| EP-1303496-B1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-12 | — | — | EP | disclosed |