Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 9/20 | 0.45 |
| ▸ | CDK1 | P06493 | 8/20 | 0.45 |
| ▸ | KDR | P35968 | 7/20 | 0.45 |
| ▸ | SYK | P43405 | 3/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.44 |
| ▸ | MARK3 | P27448 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.43 |
| ▸ | PDE5A | O76074 | 2/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.43 |
| ▸ | CDK9 | P50750 | 2/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 2/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
| ▸ | CDK7 | P50613 | 1/20 | 0.42 |
| ▸ | CCNH | P51946 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4774317 | 0.89 | AURKA (0.53) | AURKACDK2CDK1KDRSYK | |
| SCHEMBL4766065 | 0.86 | AURKA (0.50) | AURKACDK2CDK1KDRSYK | |
| SCHEMBL4772582 | 0.85 | AURKA (0.52) | AURKACDK2CDK1KDRSYK | |
| SCHEMBL4766530 | 0.84 | AURKA (0.55) | AURKACDK2CDK1KDRSYK | |
| SCHEMBL4769260 | 0.84 | CA2 (0.48) | AURKACDK2CDK1KDRSYK | |
| SCHEMBL4774057 | 0.83 | PRKCQ (0.56) | AURKACDK2CDK1KDRSYK | |
| SCHEMBL4768983 | 0.80 | AURKA (0.53) | AURKACDK2CDK1KDRSYK | |
| SCHEMBL4764044 | 0.79 | SYK (0.66) | AURKACDK2SYKPTK2CCNE1 | |
| SCHEMBL4773980 | 0.79 | AURKA (0.52) | AURKACDK2CDK1KDRSYK | |
| SCHEMBL4772264 | 0.79 | AURKA (0.47) | AURKACDK2CDK1KDRSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303496-B9 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| EP-1303496-B1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-12 | — | — | EP | disclosed |