Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 5/20 | 0.56 |
| ▸ | SYK | P43405 | 5/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.45 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4774317 | 0.87 | AURKA (0.53) | SYKAURKAPTK2KCNH2PTK2B | |
| SCHEMBL4766065 | 0.84 | AURKA (0.50) | SYKAURKAPTK2PTK2BCHEK1 | |
| SCHEMBL4764044 | 0.84 | SYK (0.66) | SYKAURKAPTK2KCNH2PTK2B | |
| SCHEMBL4772582 | 0.83 | AURKA (0.52) | SYKAURKAPTK2KDRCDK2 | |
| SCHEMBL4766388 | 0.83 | AURKA (0.49) | SYKAURKAPTK2KDRCDK2 | |
| SCHEMBL4766530 | 0.82 | AURKA (0.55) | SYKAURKALRRK2KDRCDK2 | |
| SCHEMBL4769260 | 0.82 | CA2 (0.48) | SYKAURKAPTK2CHEK1KDR | |
| SCHEMBL4770586 | 0.81 | CCNA2 (0.59) | PRKCQCHEK1CDK2 | |
| SCHEMBL4768983 | 0.78 | AURKA (0.53) | PRKCQSYKAURKAPTK2PTK2B | |
| SCHEMBL4773980 | 0.77 | AURKA (0.52) | PRKCQSYKAURKAPTK2PTK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303496-B9 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| EP-1303496-B1 | PYRIMIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-12 | — | — | EP | disclosed |