Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.67 |
| ▸ | HPGD | P15428 | 2/20 | 0.67 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.49 |
| ▸ | RAF1 | P04049 | 3/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.49 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.49 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.49 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MAT2A | P31153 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1068923 | 0.81 | KDM4E (1.00) | KDM4ESMN1; SMN2HPGDMAPK13RAF1 | |
| SCHEMBL4766017 | 0.80 | KDM4E (0.46) | KDM4ESMN1; SMN2HPGDLMNAHIF1A | |
| SCHEMBL26456444 | 0.79 | NPY5R (0.51) | KDM4ESMN1; SMN2HPGDMAPK13MAPK12 | |
| SCHEMBL38662232 | 0.78 | TGFBR1 (0.49) | KDM4ESMN1; SMN2HPGDMAPK13RAF1 | |
| SCHEMBL25302190 | 0.78 | SYK (0.44) | KDM4ESMN1; SMN2HPGDMAPK13MAPK12 | |
| SCHEMBL38664205 | 0.77 | MAPK13 (0.46) | KDM4ESMN1; SMN2HPGDMAPK13RAF1 | |
| SCHEMBL6757498 | 0.77 | KDM4E (0.49) | KDM4ESMN1; SMN2HPGDTGFBR1LMNA | |
| SCHEMBL38661053 | 0.77 | KDM4E (0.49) | KDM4ESMN1; SMN2HPGDMAPK13RAF1 | |
| SCHEMBL1387860 | 0.77 | KDM4E (0.83) | KDM4ESMN1; SMN2HPGDMAPK13RAF1 | |
| SCHEMBL18292652 | 0.75 | MAPK14 (0.61) | SMN1; SMN2MAPK13RAF1MAPK9MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120122212-A1 | TGF-BETA PATHWAY INHIBITORS FOR ENHANCEMENT OF CELLULAR REPROGRAMMING OF HUMAN CELLS | IPIERIAN, INC. | 2012-05-17 | — | — | US | disclosed |