Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4762162 | 0.88 | MAPK1 (0.41) | MAPK1AAK1CTSSCTSKMEN1 | |
| SCHEMBL6593215 | 0.82 | MAPK1 (0.36) | MAPK1MEN1KMT2A | |
| SCHEMBL6610801 | 0.81 | MBTPS1 (0.34) | NPC1 | |
| SCHEMBL6610800 | 0.81 | MBTPS1 (0.34) | NPC1 | |
| SCHEMBL6610805 | 0.81 | CD274 (0.33) | SCN9A | |
| SCHEMBL6588445 | 0.81 | MAPK1 (0.38) | MAPK1AAK1CTSKMEN1KMT2A | |
| SCHEMBL4212772 | 0.77 | CTSS (0.35) | MAPK1AAK1SCN9ACTSSCTSK | |
| SCHEMBL5971691 | 0.76 | MAPK1 (0.36) | MAPK1CTSSCTSKMEN1KMT2A | |
| SCHEMBL6611358 | 0.75 | MAPK1 (0.36) | MAPK1AAK1PSMB5 | |
| SCHEMBL4766735 | 0.75 | CTSK (0.38) | MAPK1CTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1320370-A4 | METHOD OF TREATMENT | SMITHKLINE BEECHAM CORP (US) | 2008-10-22 | — | — | EP | disclosed |
| EP-1320370-A1 | METHOD OF TREATMENT | SmithKline Beecham Corporation (US) | 2003-06-25 | — | — | EP | disclosed |
| WO-2002017924-A1 | METHOD OF TREATMENT | SMITHKLINE BEECHAM CORPORATION (GB) | 2002-03-07 | — | — | WO | disclosed |