Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | REN | P00797 | 3/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | XBP1 | P17861 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5971691 | 0.83 | MAPK1 (0.36) | MAPK1CTSKSMN1; SMN2ALDH1A1REN | |
| SCHEMBL4762162 | 0.83 | MAPK1 (0.41) | MAPK1CTSKRENAAK1MAPT | |
| SCHEMBL4766735 | 0.82 | CTSK (0.38) | MAPK1CTSKALDH1A1REN | |
| SCHEMBL4766632 | 0.81 | NPC1 (0.41) | MAPK1CTSKAAK1MEN1KMT2A | |
| SCHEMBL6593215 | 0.79 | MAPK1 (0.36) | MAPK1ALDH1A1RENLMNAKDM4E | |
| SCHEMBL6611358 | 0.77 | MAPK1 (0.36) | MAPK1ALDH1A1RENAAK1LMNA | |
| SCHEMBL4212772 | 0.74 | CTSS (0.35) | MAPK1CTSKALDH1A1AAK1LMNA | |
| SCHEMBL3955650 | 0.73 | CTSL (0.36) | MAPK1CTSKAAK1 | |
| SCHEMBL3955653 | 0.73 | CTSL (0.36) | MAPK1CTSKAAK1 | |
| SCHEMBL5971129 | 0.73 | REN (0.41) | MAPK1CTSKRENKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1307204-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2004-06-02 | — | — | EP | disclosed |
| EP-1307204-A1 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2003-05-07 | — | — | EP | disclosed |
| WO-2001095911-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-12-20 | — | — | WO | disclosed |