Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 5/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | REN | P00797 | 8/20 | 0.36 |
| ▸ | CTSB | P07858 | 2/20 | 0.35 |
| ▸ | CTSS | P25774 | 2/20 | 0.35 |
| ▸ | CTSL | P07711 | 2/20 | 0.35 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6589591 | 0.88 | CTSK (0.34) | CTSKRENCTSBCTSSCTSL | |
| SCHEMBL6588445 | 0.82 | MAPK1 (0.38) | CTSKMAPK1RENALDH1A1 | |
| SCHEMBL6606704 | 0.82 | CTSK (0.33) | CTSKCTSBCTSSCTSL | |
| SCHEMBL6590880 | 0.78 | CTSK (0.37) | CTSKMAPK1CTSBCTSSCTSL | |
| SCHEMBL5971691 | 0.78 | MAPK1 (0.36) | CTSKMAPK1RENCTSBCTSS | |
| SCHEMBL4762162 | 0.77 | MAPK1 (0.41) | CTSKMAPK1RENCTSBCTSS | |
| SCHEMBL6605289 | 0.77 | SLC6A2 (0.34) | CTSKCTSBCTSSCTSL | |
| SCHEMBL6589085 | 0.76 | HCRTR1 (0.33) | CTSKCTSBCTSSCTSL | |
| SCHEMBL4766632 | 0.75 | NPC1 (0.41) | CTSKMAPK1CTSS | |
| SCHEMBL4689761 | 0.74 | CTSK (0.63) | CTSKMAPK1CTSBCTSSCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1320370-A4 | METHOD OF TREATMENT | SMITHKLINE BEECHAM CORP (US) | 2008-10-22 | — | — | EP | disclosed |
| EP-1320370-A1 | METHOD OF TREATMENT | SmithKline Beecham Corporation (US) | 2003-06-25 | — | — | EP | disclosed |
| WO-2002017924-A1 | METHOD OF TREATMENT | SMITHKLINE BEECHAM CORPORATION (GB) | 2002-03-07 | — | — | WO | disclosed |