Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FBP1 | P09467 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL967548 | 0.71 | PDPK1 (0.38) | FBP1 | |
| SCHEMBL15173885 | 0.64 | HPGDS (0.33) | FBP1 | |
| SCHEMBL21547865 | 0.62 | ACHE (0.41) | — | |
| SCHEMBL21366258 | 0.58 | PIK3CG (0.42) | — | |
| SCHEMBL1002367 | 0.58 | FBP1 (0.33) | FBP1 | |
| SCHEMBL572719 | 0.57 | PDPK1 (0.45) | — | |
| SCHEMBL15174279 | 0.56 | BCHE (0.39) | FBP1 | |
| SCHEMBL9059095 | 0.56 | ALDH1A1 (0.50) | — | |
| SCHEMBL569960 | 0.56 | NPC1 (0.48) | — | |
| SCHEMBL9464747 | 0.54 | FBP1 (0.33) | FBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6613776-B2 | Protein serine/threonine kinase inhibitors used for treating diseases such as cancer, diabetes and Alzheimer's disease | VERTEX PHARMACEUTICALS INCORPORATED | 2003-09-02 | — | — | US | claimed |
| EP-1927594-A1 | 1,2,3-Trisubstituted aryl and heteroaryl derivatives as modulators of metabolism and the prophylaxis and treatment of disorders related thereto such as diabetes and hyperglycemia | Arena Pharmaceuticals, Inc. (US) | 2008-06-04 | — | — | EP | disclosed |
| EP-1325008-A1 | PIPERAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-07-09 | — | — | EP | disclosed |
| WO-2002010169-A1 | PIPERAZINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-02-07 | — | — | WO | disclosed |
| US-5491123-A | Herbicides containing 3-aminobenzo(B)thiophenes as antidotes | BASF AKTIENGESELLSCHAFT (DE) | 1996-02-13 | — | — | US | disclosed |