Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | TXN | P10599 | 1/20 | 0.39 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.39 |
| ▸ | ADK | P55263 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | FDPS | P14324 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | F2RL1 | P55085 | 3/20 | 0.36 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4765782 | 0.81 | HPGD (0.51) | HPGDMAPTSMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL9011939 | 0.81 | HDAC1 (0.45) | HPGDADRA2AADRA2BADRA2CHDAC1 | |
| SCHEMBL9012401 | 0.78 | HDAC1 (0.52) | HPGDMAPTHDAC1FDPSSMN1; SMN2 | |
| SCHEMBL9013455 | 0.78 | LMNA (0.41) | HPGDMAPTHDAC1TXNTXNRD1 | |
| SCHEMBL9012067 | 0.78 | HDAC1 (0.46) | HPGDADRA2AADRA2BADRA2CHDAC1 | |
| SCHEMBL9012190 | 0.74 | HDAC1 (0.44) | HPGDADRA2AADRA2CHDAC1TXN | |
| SCHEMBL229404 | 0.74 | HDAC1 (0.53) | HDAC1TAAR1NPC1ALDH1A1RAB9A | |
| SCHEMBL9012538 | 0.72 | HDAC1 (0.42) | HPGDADRA2AADRA2CHDAC1TXN | |
| SCHEMBL30435561 | 0.72 | FDPS (0.41) | HPGDHDAC1TXNTXNRD1TAAR1 | |
| Hydrochloric Acid SCHEMBL5155818 | 0.72 | HDAC1 (0.52) | HDAC1TAAR1SMN1; SMN2NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1971596-A2 | FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS MINERALOCORTICOID RECEPTOR LIGANDS | Takeda Pharmaceutical Company Limited (JP) | 2008-09-24 | — | — | EP | disclosed |
| WO-2007077961-A2 | FUSED HETEROCYCLIC COMPOUNDS AND THEIR USE AS MINERALOCORTICOID RECEPTOR LIGANDS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-07-12 | — | — | WO | disclosed |