Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.39 |
| ▸ | TDP2 | O95551 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.36 |
| ▸ | FYN | P06241 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | RPA1 | P27694 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28769083 | 0.79 | TDP2 (0.37) | PTGS2TDP2PTGS1PIK3CARPA1 | |
| SCHEMBL5058630 | 0.78 | GRM2 (0.38) | PTGS2PTGS1FYNALDH1A1MAPT | |
| SCHEMBL4770057 | 0.78 | S1PR4 (0.37) | ALDH1A1MAPTHTTRAB9AMEN1 | |
| SCHEMBL4759176 | 0.78 | MAPK14 (0.36) | MAPT | |
| SCHEMBL5058627 | 0.77 | PTGS2 (0.36) | PTGS2TDP2IDO1TDO2PTGS1 | |
| SCHEMBL4794338 | 0.75 | MAPK14 (0.41) | TDP2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27703115 | 0.75 | MAPT (0.39) | PTGS1MAPTNPC1RAB9A | |
| SCHEMBL4225394 | 0.75 | AQP1 (0.51) | PTGS2PTGS1FYNALDH1A1 | |
| SCHEMBL4772006 | 0.74 | TP53 (0.34) | ALDH1A1MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4220627 | 0.74 | AQP1 (0.43) | PTGS2PTGS1FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871355-A1 | NEW THERAPEUTIC COMBIANATIONS FOR THE TREATMENT OR PREVENTION OF DEPRESSION | Wyeth (US) | 2008-01-02 | — | — | EP | claimed |
| WO-2006116149-A1 | NEW THERAPEUTIC COMBIANATIONS FOR THE TREATMENT OR PREVENTION OF DEPRESSION | WYETH (US) | 2006-11-02 | — | — | WO | claimed |